Tag: Dissolution Rate

Troubleshooting Non-Conformance in Dissolution Testing Protocols

May 26, 2025 Admin

Troubleshooting Non-Conformance in Dissolution Testing Protocols Troubleshooting Non-Conformance in Dissolution Testing Protocols Introduction: Dissolution testing plays a crucial role in the pharmaceutical industry, ensuring that solid dosage forms like tablets release their active ingredients at the desired rate. When these protocols encounter non-conformance, it can lead to significant setbacks in drug development and manufacturing. Understanding…

Solid Dosage form, Tablets

Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing

April 30, 2025 Admin

Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing Introduction: The pharmaceutical industry constantly strives to develop effective drug delivery mechanisms, with enteric-coated tablets serving as a crucial form of solid dosage. These tablets are designed to resist the acidic environment of the stomach, releasing their active ingredients…

Solid Dosage form, Tablets

Ensuring Adequacy of Binder Distribution in Sustained Release Tablet Validation

April 19, 2025 Admin

Ensuring Adequacy of Binder Distribution in Sustained Release Tablet Validation Ensuring Adequacy of Binder Distribution in Sustained Release Tablet Validation Introduction: In the complex world of pharmaceutical manufacturing, sustained release tablets represent a crucial advancement in medication delivery systems. These tablets offer numerous benefits, including improved patient compliance and enhanced bioavailability. However, the validation of…

Solid Dosage form, Tablets

Problems with testing capsules containing high API load.

April 13, 2025 Admin

Problems with testing capsules containing high API load. Problems with testing capsules containing high API load. Introduction: In the pharmaceutical industry, capsules are a popular solid oral dosage form due to their versatility and ease of administration. As the demand for high-dose medications increases, the challenge of creating capsules with a high Active Pharmaceutical Ingredient…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Optimizing Compression Force for Extended Release Tablet Uniformity

March 25, 2025 Admin

Optimizing Compression Force for Extended Release Tablet Uniformity Optimizing Compression Force for Extended Release Tablet Uniformity Introduction: Extended release tablets are a vital component of modern pharmaceutical therapies, designed to release their active ingredients at a predetermined rate to maintain a consistent drug concentration in the bloodstream. Ensuring the uniformity of these tablets is crucial,…

Solid Dosage form, Tablets

Troubleshooting Variability in Dissolution Profiles During Stability Studies

March 14, 2025 Admin

Troubleshooting Variability in Dissolution Profiles During Stability Studies Troubleshooting Variability in Dissolution Profiles During Stability Studies Introduction: Dissolution testing is a critical aspect of pharmaceutical development, acting as a quality control measure to ensure that tablets release their active ingredients at the intended rate and extent. During stability studies, the variability in dissolution profiles can…

Solid Dosage form, Tablets

Common Dissolution Failures in Immediate Release Tablets

March 9, 2025 Admin

Common Dissolution Failures in Immediate Release Tablets Common Dissolution Failures in Immediate Release Tablets Introduction: Immediate release tablets are a cornerstone of oral pharmaceutical dosage forms, designed to disintegrate and release their active ingredients promptly upon ingestion. The dissolution process plays a critical role in ensuring the therapeutic efficacy and bioavailability of these tablets. However,…

Solid Dosage form, Tablets

Resolving Non-Compliance in Dissolution Testing for Extended Release Tablets

March 7, 2025 Admin

Resolving Non-Compliance in Dissolution Testing for Extended Release Tablets Resolving Non-Compliance in Dissolution Testing for Extended Release Tablets Introduction: In the pharmaceutical industry, dissolution testing is a critical quality control measure, especially for extended release tablets. This testing ensures that the drug releases its active ingredients at the desired rate and duration, which is essential…

Solid Dosage form, Tablets

Preventing Non-Homogeneity in Blends for Controlled Release Tablets

March 5, 2025 Admin

Preventing Non-Homogeneity in Blends for Controlled Release Tablets Preventing Non-Homogeneity in Blends for Controlled Release Tablets Introduction: Controlled release tablets are at the forefront of modern pharmaceutical development due to their ability to deliver therapeutic agents at a regulated pace, enhancing patient compliance and therapeutic efficacy. However, achieving uniform distribution of active pharmaceutical ingredients (APIs)…

Solid Dosage form, Tablets

Managing Over-Lubrication in Blending Processes for Compression

March 2, 2025 Admin

Managing Over-Lubrication in Blending Processes for Compression Managing Over-Lubrication in Blending Processes for Compression Introduction: In the realm of pharmaceutical manufacturing, ensuring the quality and efficacy of solid dosage forms like tablets is paramount. The blending process, a critical step in tablet production, often involves the use of lubricants to improve the flow of powder…

Solid Dosage form, Tablets