Tag: Disintegration time

Importance of Using Appropriate Lubricants in Tablet Compression Lubricants play a crucial role in tablet compression, as they help facilitate the tablet manufacturing process and ensure the production of high-quality tablets. Lubricants are added to tablet formulations to reduce friction between the tablet granules and the surfaces of the tablet punches and dies during compression….

Read More “Explain the importance of using appropriate lubricants in tablet compression.” »

Troubleshooting Tablet Sticking During Compression Tablet sticking during compression can be a common problem in tablet manufacturing. It occurs when the tablet blend adheres to the punch faces, leading to difficulties in ejecting the tablets from the dies and affecting tablet quality. Troubleshooting tablet sticking involves identifying the root cause and implementing corrective actions. Here…

Read More “How do you troubleshoot tablet sticking during compression?” »

Guidelines for Good Tablet Manufacturing Practices Good Tablet Manufacturing Practices (GTMP) are a set of guidelines and standards established to ensure the quality, safety, and efficacy of pharmaceutical tablets. Compliance with GTMP is essential to meet regulatory requirements, maintain product consistency, and protect public health. Here are some of the key guidelines for good tablet…

Read More “What are the guidelines for good tablet manufacturing practices?” »

Different Methods of Tablet Coating Tablet coating is a process used to apply a thin layer of coating material onto the surface of tablets. The coating can serve various purposes, including improving tablet appearance, taste masking, providing gastro-resistance, or modifying drug release characteristics. There are different methods of tablet coating, each with its own advantages…

Read More “What are the different methods of tablet coating?” »

Tablet Stability Testing Tablet stability testing is a critical aspect of pharmaceutical development and quality control. It involves evaluating the chemical, physical, and microbiological properties of tablets over time to ensure their quality, safety, and effectiveness throughout their shelf life. The stability testing process follows established guidelines and regulatory requirements to assess how the tablets…

Read More “How is tablet stability determined and tested?” »

Role of Lubricants in Tablet Compression Lubricants play a crucial role in tablet compression, as they are essential for ensuring the smooth and efficient operation of the tablet manufacturing process. Lubricants are inactive ingredients added to the tablet formulation to reduce friction between the tablet blend and the surfaces of the tablet press during compression….

Read More “Explain the role of lubricants in tablet compression.” »

Identification and Rectification of Tablet Defects Tablet defects can arise during tablet manufacturing due to various factors, including formulation issues, process challenges, equipment problems, and environmental conditions. Identifying and rectifying tablet defects are crucial to ensure the production of high-quality tablets that meet the required specifications and regulatory standards. Here are the steps involved in…

Read More “How are tablet defects identified and rectified?” »

Key Elements of Tablet Formulation Development Process The tablet formulation development process is a critical stage in the pharmaceutical product development life cycle. It involves designing a tablet formulation that ensures the stability, bioavailability, safety, and effectiveness of the drug product. The process requires careful consideration of various factors and the integration of scientific principles…

Read More “What are the key elements of a tablet formulation development process?” »

Critical Factors Affecting Tablet Uniformity during Production Achieving tablet uniformity during production is essential to ensure that each tablet in a batch contains the correct amount of active pharmaceutical ingredient (API) and other excipients. Tablet uniformity directly impacts the drug’s efficacy, safety, and patient compliance. Several critical factors can influence tablet uniformity during production, and…

Read More “What are the critical factors affecting tablet uniformity during production?” »

Tablet Dissolution Testing Tablet dissolution testing is a critical quality control test used to assess the rate at which a tablet disintegrates and releases its active pharmaceutical ingredient (API) in a specified dissolution medium. It provides valuable information about the tablet’s drug release profile, which is essential for ensuring the tablet’s bioavailability and effectiveness. Here’s…

Read More “How is tablet dissolution testing performed?” »

Preparation of Enteric-Coated Tablets Introduction to Enteric-Coated Tablets Enteric-coated tablets are designed to bypass the acidic environment of the stomach and release the medication in the alkaline environment of the small intestine. This coating is essential for drugs that are sensitive to stomach acid or cause gastric irritation. The enteric coating allows for delayed or…

Read More “How are enteric-coated tablets prepared?” »

Tablet Weight Uniformity and Acceptance Criteria Tablet weight uniformity is a critical quality control parameter in tablet manufacturing. It refers to the consistency of the weight of individual tablets within a batch. Ensuring tablet weight uniformity is essential because variations in tablet weight can lead to differences in drug content, which can affect the drug’s…

Read More “Explain the concept of tablet weight uniformity and its acceptance criteria.” »