Tag: Disintegration time

Ensuring Robustness in Disintegration Time During Validation Testing

May 24, 2025 Admin

Ensuring Robustness in Disintegration Time During Validation Testing Ensuring Robustness in Disintegration Time During Validation Testing Introduction: In the pharmaceutical industry, the disintegration time of tablets is a critical quality attribute that directly impacts drug release and bioavailability. Ensuring robustness in disintegration time during validation testing is essential to maintain consistency in therapeutic efficacy and…

Solid Dosage form, Tablets

Ensuring Consistency in Disintegration Time During Long-Term Stability Studies

May 3, 2025 Admin

Ensuring Consistency in Disintegration Time During Long-Term Stability Studies Ensuring Consistency in Disintegration Time During Long-Term Stability Studies Introduction: In the realm of pharmaceuticals, ensuring consistency in the disintegration time of tablets during long-term stability studies is pivotal for guaranteeing a drug’s efficacy, safety, and patient compliance. Disintegration time is a critical quality attribute that…

Solid Dosage form, Tablets

Resolving Disintegration Failures in Sugar-Coated Tablets During Stability Testing

April 21, 2025 Admin

Resolving Disintegration Failures in Sugar-Coated Tablets During Stability Testing Resolving Disintegration Failures in Sugar-Coated Tablets During Stability Testing Introduction: Sugar-coated tablets are a popular dosage form in the pharmaceutical industry, valued for their aesthetic appeal and ability to mask unpleasant tastes. However, these advantages can be overshadowed by challenges encountered during stability testing, particularly disintegration…

Solid Dosage form, Tablets

Identifying Causes of Poor Disintegration in Controlled Release Tablets

March 27, 2025 Admin

Identifying Causes of Poor Disintegration in Controlled Release Tablets Identifying Causes of Poor Disintegration in Controlled Release Tablets Introduction: In the realm of pharmaceuticals, controlled release tablets have become a cornerstone of modern drug delivery systems. These formulations are designed to release the active pharmaceutical ingredient (API) at a predetermined rate, providing therapeutic benefits over…

Solid Dosage form, Tablets

Identifying Causes of Tablet Swelling During Disintegration Testing

March 17, 2025 Admin

Identifying Causes of Tablet Swelling During Disintegration Testing Identifying Causes of Tablet Swelling During Disintegration Testing Introduction: In the pharmaceutical industry, ensuring the quality and efficacy of solid dosage forms, such as tablets, is paramount. A critical aspect of this quality control is disintegration testing, a process that evaluates how quickly a tablet breaks down…

Solid Dosage form, Tablets

Poor reproducibility in monitoring capsule disintegration times.

March 16, 2025 Admin

Poor reproducibility in monitoring capsule disintegration times. Poor reproducibility in monitoring capsule disintegration times. Introduction: In the realm of pharmaceutical research and manufacturing, ensuring the quality and efficacy of solid oral dosage forms is paramount. Among these, capsules, both hard and soft gelatin, are widely used due to their convenience and efficacy in drug delivery….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in monitoring capsule disintegration profiles.

March 6, 2025 Admin

Poor reproducibility in monitoring capsule disintegration profiles. Poor reproducibility in monitoring capsule disintegration profiles. Introduction: The disintegration profile of capsules is a critical quality attribute that significantly impacts the bioavailability and therapeutic efficacy of the drug product. Ensuring consistent and reproducible disintegration times is essential for achieving regulatory compliance and maintaining product quality. Despite its…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

What are the advantages of using pre-formulated direct compression excipients?

August 22, 2023August 5, 2023 Admin

Advantages of Using Pre-formulated Direct Compression Excipients Pre-formulated direct compression excipients are ready-to-use blends of various excipients specifically designed for direct compression tablet manufacturing. These pre-formulated excipients offer several advantages over traditional individual excipients. Here are the key advantages of using pre-formulated direct compression excipients: 1. Simplified Formulation Development Pre-formulated excipients streamline the tablet formulation…

Tablets

How are multi-layer tablets manufactured?

August 22, 2023August 5, 2023 Admin

Manufacturing Process of Multi-Layer Tablets Multi-layer tablets are pharmaceutical tablets that consist of two or more distinct layers of different drug formulations. These layers may release the active pharmaceutical ingredients (APIs) at different rates or provide other specific functionalities, such as immediate release followed by sustained release. The manufacturing process of multi-layer tablets involves careful…

Tablets

What are the different tablet scoring techniques?

August 22, 2023August 5, 2023 Admin

Different Tablet Scoring Techniques Tablet scoring is a process used to create a groove or shallow indentation on a tablet’s surface. The scoring facilitates breaking the tablet into smaller parts, allowing patients to adjust the dose as needed. Tablet scoring is particularly useful for patients who have difficulty swallowing or need a lower dosage strength…

Tablets

How are sustained-release tablets formulated?

August 21, 2023August 5, 2023 Admin

Formulation of Sustained-Release Tablets Sustained-release tablets, also known as extended-release tablets or controlled-release tablets, are designed to release the active pharmaceutical ingredient (API) over an extended period, maintaining a steady and controlled drug release profile. The formulation of sustained-release tablets requires careful selection of excipients and incorporation of drug release mechanisms to achieve the desired…

Tablets

What is the purpose of using glidants in tablet manufacturing?

August 20, 2023August 5, 2023 Admin

Purpose of Using Glidants in Tablet Manufacturing Glidants, also known as lubricating glidants or flow aids, are additives used in tablet manufacturing to improve the flow properties of the tablet blend. They serve the crucial purpose of enhancing the flowability of powders or granules, making the tablet manufacturing process more efficient and consistent. Glidants play…

Tablets