Tag: Direct compression

Advantages of Using Pre-formulated Direct Compression Excipients Pre-formulated direct compression excipients are ready-to-use blends of various excipients specifically designed for direct compression tablet manufacturing. These pre-formulated excipients offer several advantages over traditional individual excipients. Here are the key advantages of using pre-formulated direct compression excipients: 1. Simplified Formulation Development Pre-formulated excipients streamline the tablet formulation…

Read More “What are the advantages of using pre-formulated direct compression excipients?” »

Manufacturing Process of Multi-Layer Tablets Multi-layer tablets are pharmaceutical tablets that consist of two or more distinct layers of different drug formulations. These layers may release the active pharmaceutical ingredients (APIs) at different rates or provide other specific functionalities, such as immediate release followed by sustained release. The manufacturing process of multi-layer tablets involves careful…

Read More “How are multi-layer tablets manufactured?” »

Different Tablet Scoring Techniques Tablet scoring is a process used to create a groove or shallow indentation on a tablet’s surface. The scoring facilitates breaking the tablet into smaller parts, allowing patients to adjust the dose as needed. Tablet scoring is particularly useful for patients who have difficulty swallowing or need a lower dosage strength…

Read More “What are the different tablet scoring techniques?” »

Formulation of Sustained-Release Tablets Sustained-release tablets, also known as extended-release tablets or controlled-release tablets, are designed to release the active pharmaceutical ingredient (API) over an extended period, maintaining a steady and controlled drug release profile. The formulation of sustained-release tablets requires careful selection of excipients and incorporation of drug release mechanisms to achieve the desired…

Read More “How are sustained-release tablets formulated?” »

Purpose of Using Glidants in Tablet Manufacturing Glidants, also known as lubricating glidants or flow aids, are additives used in tablet manufacturing to improve the flow properties of the tablet blend. They serve the crucial purpose of enhancing the flowability of powders or granules, making the tablet manufacturing process more efficient and consistent. Glidants play…

Read More “What is the purpose of using glidants in tablet manufacturing?” »

Importance of Using Appropriate Lubricants in Tablet Compression Lubricants play a crucial role in tablet compression, as they help facilitate the tablet manufacturing process and ensure the production of high-quality tablets. Lubricants are added to tablet formulations to reduce friction between the tablet granules and the surfaces of the tablet punches and dies during compression….

Read More “Explain the importance of using appropriate lubricants in tablet compression.” »

Troubleshooting Tablet Sticking During Compression Tablet sticking during compression can be a common problem in tablet manufacturing. It occurs when the tablet blend adheres to the punch faces, leading to difficulties in ejecting the tablets from the dies and affecting tablet quality. Troubleshooting tablet sticking involves identifying the root cause and implementing corrective actions. Here…

Read More “How do you troubleshoot tablet sticking during compression?” »

Guidelines for Good Tablet Manufacturing Practices Good Tablet Manufacturing Practices (GTMP) are a set of guidelines and standards established to ensure the quality, safety, and efficacy of pharmaceutical tablets. Compliance with GTMP is essential to meet regulatory requirements, maintain product consistency, and protect public health. Here are some of the key guidelines for good tablet…

Read More “What are the guidelines for good tablet manufacturing practices?” »

Different Methods of Tablet Coating Tablet coating is a process used to apply a thin layer of coating material onto the surface of tablets. The coating can serve various purposes, including improving tablet appearance, taste masking, providing gastro-resistance, or modifying drug release characteristics. There are different methods of tablet coating, each with its own advantages…

Read More “What are the different methods of tablet coating?” »

Tablet Stability Testing Tablet stability testing is a critical aspect of pharmaceutical development and quality control. It involves evaluating the chemical, physical, and microbiological properties of tablets over time to ensure their quality, safety, and effectiveness throughout their shelf life. The stability testing process follows established guidelines and regulatory requirements to assess how the tablets…

Read More “How is tablet stability determined and tested?” »

Role of Lubricants in Tablet Compression Lubricants play a crucial role in tablet compression, as they are essential for ensuring the smooth and efficient operation of the tablet manufacturing process. Lubricants are inactive ingredients added to the tablet formulation to reduce friction between the tablet blend and the surfaces of the tablet press during compression….

Read More “Explain the role of lubricants in tablet compression.” »

Identification and Rectification of Tablet Defects Tablet defects can arise during tablet manufacturing due to various factors, including formulation issues, process challenges, equipment problems, and environmental conditions. Identifying and rectifying tablet defects are crucial to ensure the production of high-quality tablets that meet the required specifications and regulatory standards. Here are the steps involved in…

Read More “How are tablet defects identified and rectified?” »