Tag: Delayed-release capsules

Limited Research on Advanced Excipients for Soft Gelatin Formulations Addressing the Limited Research on Advanced Excipients for Soft Gelatin Formulations Context Soft gelatin capsules (SGCs) are a popular dosage form used to deliver a wide variety of drugs, including both liquid and solid formulations. However, the development of soft gelatin formulations that contain advanced excipients…

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High Variability in Capsule Weight Due to Uneven Fill Material Distribution Addressing High Variability in Capsule Weight Due to Uneven Fill Material Distribution Context In pharmaceutical capsule manufacturing, achieving uniform capsule weight is essential for ensuring consistent dosing, therapeutic efficacy, and regulatory compliance. Variability in capsule weight due to uneven fill material distribution can lead…

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Limited Options for Developing Natural Gelatin-Free Capsule Shells Addressing the Limited Options for Developing Natural Gelatin-Free Capsule Shells Context The demand for natural, plant-based, or vegan capsule alternatives is growing due to increased consumer awareness of dietary preferences and ethical concerns. Gelatin, derived from animal products, is traditionally used in the manufacture of capsules, but…

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High Risk of Microbial Growth During Product Development Addressing the High Risk of Microbial Growth During Product Development Context Microbial contamination is a significant concern during the development of pharmaceutical products, particularly in the case of capsule formulations that involve liquid-filled capsules or products containing moisture-sensitive ingredients. Microbial growth during product development can not only…

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Difficulty in Encapsulating Large-Dose Drugs in a Single Capsule Addressing the Difficulty in Encapsulating Large-Dose Drugs in a Single Capsule Context Encapsulating large-dose drugs in a single capsule presents significant challenges in the pharmaceutical manufacturing process. As the dose of the active pharmaceutical ingredient (API) increases, the volume of the capsule must also increase to…

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Issues with Achieving a Uniform Capsule Wall Thickness Addressing Issues with Achieving a Uniform Capsule Wall Thickness Context The consistency of capsule wall thickness is crucial for ensuring uniformity in drug release, product stability, and overall quality. Variability in capsule wall thickness can lead to inconsistent dissolution profiles, which can affect the bioavailability of the…

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Lack of Standard Excipient Grades for Lipid-Based Formulations Addressing the Lack of Standard Excipient Grades for Lipid-Based Formulations Context Lipid-based formulations are increasingly being used to improve the solubility and bioavailability of poorly water-soluble drugs. However, the formulation of lipid-based systems often faces a significant challenge in the form of a lack of standardized excipient…

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Poor Drug Release Consistency for Low-Solubility Drugs Addressing Poor Drug Release Consistency for Low-Solubility Drugs in Capsules Context Low-solubility drugs are a significant challenge in capsule formulations, as their poor solubility can lead to inconsistent drug release, which in turn impacts bioavailability and therapeutic effectiveness. The inability to achieve consistent release profiles for these drugs…

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Incompatibility of Active Ingredients with Common Shell Coloring Agents Addressing the Incompatibility of Active Ingredients with Common Shell Coloring Agents Context Capsule shell coloring agents are widely used to improve the visual appearance of pharmaceutical products, facilitate product identification, and protect light-sensitive ingredients. However, certain active pharmaceutical ingredients (APIs) can interact with coloring agents, leading…

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High Variability in Shell Thickness Affecting Dissolution Rates Addressing High Variability in Shell Thickness Affecting Dissolution Rates Context Capsule shell thickness plays a critical role in controlling the drug release profile and ensuring consistent dissolution behavior. Variability in capsule shell thickness can significantly affect the dissolution rate, leading to inconsistent drug release, and consequently, affecting…

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Limited Scalability of Innovative Capsule Dosage Forms Addressing the Limited Scalability of Innovative Capsule Dosage Forms Context While innovative capsule dosage forms, such as those incorporating advanced drug delivery systems, offer numerous advantages in terms of drug efficacy and patient compliance, scaling up these formulations from laboratory-scale development to commercial manufacturing can be challenging. Factors…

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Challenges in Achieving a Balance Between Solubility and Stability Addressing the Challenges in Achieving a Balance Between Solubility and Stability in Capsule Formulations Context In pharmaceutical formulations, especially for poorly soluble drugs, achieving an optimal balance between solubility and stability is critical to ensure both therapeutic efficacy and long-term product performance. While enhancing the solubility…

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