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Using X-Ray Crystallography in Drug Discovery Drug Discovery Using X-Ray Crystallography A Guide to Using X-Ray Crystallography for Structural Analysis X-ray crystallography is a powerful technique used in drug discovery to determine the 3D structure of biological macromolecules and drug-target complexes. By solving the crystal structure of proteins and small molecules, researchers can gain valuable…
Protein Purification for Structural Studies Guide on Protein Purification for Structural Studies How to Purify Proteins for Structural Analysis in Drug Discovery Protein purification is an essential step in drug discovery, particularly for structural studies that provide insights into drug-target interactions. Purified proteins are required for techniques such as X-ray crystallography, NMR spectroscopy, and cryo-electron…
Differential Scanning Calorimetry (DSC) in Drug Discovery Guide to Differential Scanning Calorimetry (DSC) in Drug Discovery How to Use DSC to Study Drug-Target Interactions and Stability Differential Scanning Calorimetry (DSC) is a technique used to measure the thermal properties of compounds, including their stability and interactions with biological targets. DSC provides important thermodynamic data, such…
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Performing Isothermal Titration Calorimetry (ITC) Studies How to Perform Isothermal Titration Calorimetry (ITC) Studies A Guide to Using ITC for Drug-Target Interaction Analysis Isothermal titration calorimetry (ITC) is a powerful technique used in drug discovery to study the thermodynamics of drug-target interactions. ITC provides detailed data on binding affinity, enthalpy, entropy, and stoichiometry of the…
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Conducting Surface Plasmon Resonance (SPR) Studies How to Conduct Surface Plasmon Resonance (SPR) Studies in Drug Discovery A Guide to Using SPR for Drug-Target Interaction Analysis Surface Plasmon Resonance (SPR) is a biophysical technique used to measure the real-time interaction between a drug and its target. SPR provides valuable information about binding affinity, kinetics, and…
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Biophysical Methods in Drug Discovery Guide to Biophysical Methods in Drug Discovery Applying Biophysical Techniques to Study Drug-Target Interactions Biophysical methods are powerful tools in drug discovery, providing insights into the binding, stability, and dynamics of drug-target interactions. These techniques can help identify promising drug candidates, optimize lead compounds, and understand the molecular mechanisms of…
Validating Assay Methods in Drug Discovery How to Validate Assay Methods in Drug Discovery Ensuring Reliability and Accuracy in Drug Screening Assays Assay validation is a critical step in drug discovery, ensuring that the methods used to assess drug activity are reliable, reproducible, and capable of detecting relevant biological effects. Here’s how to validate assay…
Assay Development for Target Screening Assay Development for Target Screening in Drug Discovery A Tutorial for Creating Effective Target Screening Assays Assay development is a critical step in drug discovery, as it enables the screening of compounds to identify those that modulate a specific biological target. A well-designed assay is essential for accurate, reproducible results…
How to Isolate Natural Products in Drug Discovery Isolating Natural Products in Drug Discovery A Guide to Extracting and Identifying Bioactive Natural Products Natural products have long been a source of potent drugs, particularly in the treatment of infectious diseases, cancer, and metabolic disorders. Isolating natural products from plants, microbes, and marine organisms is a…
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Microbial Screening for Antimicrobial Compounds Guide to Microbial Screening for Antimicrobial Compounds Screening Strategies for Discovering New Antimicrobial Agents Microbial screening is a critical process in drug discovery, particularly for the identification of new antimicrobial compounds. With the rise of antimicrobial resistance, there is an urgent need for novel antimicrobial agents. Microbial screening allows researchers…
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Properly Handling High-Throughput Screening Equipment Proper Handling of High-Throughput Screening Equipment A Guide to Ensuring the Efficiency and Safety of HTS Equipment High-throughput screening (HTS) is a vital tool in drug discovery, enabling the rapid testing of large compound libraries against biological targets. To ensure the success of HTS, it is crucial to handle and…
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Using Omics Data in Target Validation How to Use Omics Data in Target Validation A Guide for Incorporating Omics Data in Target Validation Omics data, including genomics, proteomics, transcriptomics, and metabolomics, has become increasingly important in drug discovery, particularly in the process of target validation. By integrating large-scale biological data, researchers can identify relevant drug…