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Formulation and Compression of Bi-Layer Tablets Bi-layer tablets are a type of pharmaceutical tablet that consists of two distinct layers with different drug formulations. Each layer serves a specific purpose, and the two layers are compressed together to form a single tablet. Here’s how bi-layer tablets are formulated and compressed: Formulation of Bi-Layer Tablets Layer…
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Advantages of Wet Granulation Wet granulation is a widely used pharmaceutical manufacturing process that involves the addition of liquid binders to powder mixtures to create granules. This process offers several advantages over other granulation techniques, such as dry granulation. 1. Improved Granule Characteristics Wet granulation facilitates the creation of granules with uniform size, shape, and…
Advantages of Dry Granulation Dry granulation is a pharmaceutical manufacturing process used to convert powdered ingredients into granules without the use of any liquid binders. This process offers several advantages over other granulation techniques, such as wet granulation. 1. Preservation of Thermally Sensitive Ingredients Dry granulation is particularly advantageous when dealing with thermally sensitive ingredients….
Tablet Capping: Causes and Prevention Tablet capping is a tablet defect that occurs during the compression process when the upper or lower part of the tablet separates horizontally from the main body, resembling a cap. It can lead to tablets with compromised integrity, reduced drug content, and poor visual appearance. Understanding the causes of tablet…
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Types of Tablet Presses Used in Manufacturing Tablet presses are essential machines used in pharmaceutical manufacturing to compress powder blends into solid tablets of various shapes and sizes. There are several types of tablet presses available, each offering specific advantages and capabilities. Here are the different types of tablet presses commonly used in tablet manufacturing:…
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Manufacturing Orally Disintegrating Tablets (ODTs) Orally disintegrating tablets (ODTs), also known as fast-dissolving or quick-dissolving tablets, are a popular dosage form designed to rapidly disintegrate and dissolve in the mouth without the need for water. ODTs offer advantages in patient convenience and compliance, especially for individuals who have difficulty swallowing traditional tablets or capsules. The…
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Factors Affecting Tablet Dissolution Rate The dissolution rate of a tablet refers to how quickly the tablet disintegrates and releases the active pharmaceutical ingredient (API) into the surrounding medium, typically water, in a laboratory test. The dissolution rate is a critical parameter as it directly impacts the drug’s bioavailability and effectiveness. Several factors can influence…
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Tablet Weight Variation and Acceptable Limits Tablet weight variation is a critical quality parameter in tablet manufacturing that measures the consistency of tablet weight among a batch of tablets. It ensures that each tablet contains the correct amount of active pharmaceutical ingredient (API) and excipients, and that the tablets deliver the intended dose to patients….
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Comparison between Effervescent Tablets and Conventional Tablets 1. Composition and Formulation: Effervescent Tablets: Effervescent tablets contain active pharmaceutical ingredients (APIs) along with effervescent agents, such as citric acid and sodium bicarbonate. These agents react with water to produce carbon dioxide gas, leading to the characteristic effervescence or fizzing. Effervescent tablets often contain additional excipients like…
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Chewable Tablets: Formulation and Overview Introduction to Chewable Tablets Chewable tablets are a type of oral solid dosage form designed to be chewed or masticated before swallowing. They are formulated to provide a convenient and palatable way of administering medication, especially for patients who have difficulty swallowing conventional tablets or capsules. Chewable tablets are commonly…
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Measurement of Tablet Hardness Using Different Techniques Tablet hardness, also known as tablet crushing strength, is an essential parameter that measures the mechanical strength and integrity of a tablet. It is an important quality control parameter in tablet manufacturing. Several techniques are available to measure tablet hardness. Here are some commonly used methods: 1. Manual…
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Role of Binders in Tablet Formulation Binders are essential excipients used in tablet formulation to impart cohesiveness to the powders in the tablet blend. They play a crucial role in ensuring that the tablet maintains its shape and integrity during and after compression. Binders are necessary because many active pharmaceutical ingredients (APIs) and other excipients…
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