Tag: Capsule tamper-evidence

Problems with Capsule Crushing During Disintegration Testing Addressing Problems with Capsule Crushing During Disintegration Testing Context Capsule disintegration testing is a critical part of quality control in the pharmaceutical industry,…

Inadequate Methods for Testing Volatile Fill Materials Addressing Inadequate Methods for Testing Volatile Fill Materials Context Capsules, especially soft gelatin capsules, often contain volatile fill materials such as essential oils,…

Poor Correlation Between In Vitro and In Vivo Dissolution Profiles Addressing Poor Correlation Between In Vitro and In Vivo Dissolution Profiles Context The correlation between in vitro dissolution and in…

Challenges in Accurately Measuring Moisture Migration During Stability Studies Addressing Challenges in Accurately Measuring Moisture Migration During Stability Studies Context Moisture migration in pharmaceutical products, particularly in capsule formulations, is…

Problems with Achieving Uniform Sampling for Content Uniformity Tests Addressing Problems with Achieving Uniform Sampling for Content Uniformity Tests Context Content uniformity testing is essential in the pharmaceutical industry to…

Lack of Sensitivity in Microbial Limit Testing for Capsules Addressing the Lack of Sensitivity in Microbial Limit Testing for Capsules Context Microbial limit testing (MLT) is a crucial step in…

Difficulty in Testing Capsules with Very Low Fill Weights Addressing the Difficulty in Testing Capsules with Very Low Fill Weights Context Capsules with very low fill weights, typically used for…

Issues with Method Validation for Multi-Component Capsule Formulations Addressing Issues with Method Validation for Multi-Component Capsule Formulations Context Multi-component capsule formulations, which contain two or more active pharmaceutical ingredients (APIs)…

Difficulty in Distinguishing Between Capsule Cap and Body During Testing Addressing the Difficulty in Distinguishing Between Capsule Cap and Body During Testing Context Capsules are one of the most common…

Challenges in Testing Capsules with Modified-Release Coatings Addressing Challenges in Testing Capsules with Modified-Release Coatings Context Modified-release capsules are designed to release the active pharmaceutical ingredient (API) in a controlled…

Inconsistent Results in Assay Testing Due to API Degradation During Analysis Addressing Inconsistent Results in Assay Testing Due to API Degradation During Analysis Context Assay testing is a crucial quality…

Poor Reproducibility in Friability Testing of Filled Capsules Addressing Poor Reproducibility in Friability Testing of Filled Capsules Context Friability testing is an essential quality control test used to assess the…