Tag: capsule stability

Poor correlation between in vitro dissolution and stability data.

April 24, 2025 Admin

Poor correlation between in vitro dissolution and stability data. Poor correlation between in vitro dissolution and stability data. Introduction: In the pharmaceutical industry, the correlation between in vitro dissolution and stability data is pivotal for ensuring the efficacy and safety of solid oral dosage forms, particularly capsules. Dissolution testing is a key quality control measure…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for monitoring capsule weight loss due to evaporation.

April 23, 2025 Admin

Inadequate systems for monitoring capsule weight loss due to evaporation. Inadequate Systems for Monitoring Capsule Weight Loss Due to Evaporation Introduction: Capsules, both hard and soft gelatin, are among the most popular solid oral dosage forms in the pharmaceutical industry, renowned for their ease of administration and ability to encapsulate a wide range of formulations….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in evaluating the stability of multi-particulate capsules.

April 23, 2025 Admin

Difficulty in evaluating the stability of multi-particulate capsules. Difficulty in evaluating the stability of multi-particulate capsules Introduction: In the pharmaceutical industry, ensuring the stability of drug products is crucial for maintaining their efficacy, safety, and quality over their shelf life. Multi-particulate capsules, which contain numerous small, discrete particles within a single dosage form, offer several…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of temperature sensors in capsule drying ovens.

April 22, 2025 Admin

Poor validation of temperature sensors in capsule drying ovens. Poor validation of temperature sensors in capsule drying ovens. Introduction: Temperature control is a critical aspect of pharmaceutical manufacturing, especially in the drying of capsules. Accurate temperature monitoring ensures the quality and efficacy of both hard and soft gelatin capsules. However, poor validation of temperature sensors…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in preventing contamination of capsule packs during sealing.

April 22, 2025 Admin

Difficulty in preventing contamination of capsule packs during sealing. Difficulty in preventing contamination of capsule packs during sealing. Introduction: In the pharmaceutical industry, ensuring the integrity and safety of products is paramount. Capsules, both hard and soft gelatin, are a popular solid oral dosage form due to their ease of administration and ability to mask…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in maintaining consistent capsule appearance during production.

April 21, 2025 Admin

Difficulty in maintaining consistent capsule appearance during production. Difficulty in maintaining consistent capsule appearance during production. Introduction: Capsule appearance is a critical quality attribute in pharmaceutical manufacturing. The appearance not only reflects the aesthetic qualities of the product but also its safety, efficacy, and compliance with regulatory standards. Inconsistent capsule appearance during production can lead…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in assessing the stability of capsules containing low-dose APIs.

April 21, 2025 Admin

Difficulty in assessing the stability of capsules containing low-dose APIs. Difficulty in assessing the stability of capsules containing low-dose APIs. Introduction: In the pharmaceutical industry, ensuring the stability of drug products is paramount, particularly when dealing with capsules containing low-dose Active Pharmaceutical Ingredients (APIs). Stability refers to the ability of a drug product to maintain…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor correlation between laboratory and field stability data for capsules.

April 20, 2025 Admin

Poor correlation between laboratory and field stability data for capsules. Poor correlation between laboratory and field stability data for capsules. Introduction: In the pharmaceutical industry, stability testing is a critical component that ensures the safety, efficacy, and quality of drug products throughout their shelf life. Capsules, both hard and soft gelatin, are popular solid oral…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring compliance with packaging material standards for capsules.

April 20, 2025 Admin

Difficulty in ensuring compliance with packaging material standards for capsules. Difficulty in ensuring compliance with packaging material standards for capsules Introduction: In the pharmaceutical industry, ensuring compliance with packaging material standards for capsules is crucial for maintaining product integrity, efficacy, and safety. Capsules, whether hard or soft gelatin, are sensitive to environmental factors like humidity,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in validation data for capsule storage equipment.

April 18, 2025 Admin

Poor reproducibility in validation data for capsule storage equipment. Poor reproducibility in validation data for capsule storage equipment. Introduction: The pharmaceutical industry relies heavily on precise and reliable data to ensure the safety and efficacy of its products. One critical area where data integrity is paramount is in the storage of capsules, both hard and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in assessing stability of capsules with non-aqueous fills.

April 18, 2025 Admin

Challenges in assessing stability of capsules with non-aqueous fills. Challenges in assessing stability of capsules with non-aqueous fills. Introduction: In the pharmaceutical industry, ensuring the stability of drug products is crucial for maintaining efficacy and safety. Capsules, both hard and soft gelatin, are popular solid oral dosage forms. However, when these capsules are filled with…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in maintaining consistent quality for multi-particulate capsules.

April 18, 2025 Admin

Challenges in maintaining consistent quality for multi-particulate capsules. Challenges in maintaining consistent quality for multi-particulate capsules. Introduction: In the pharmaceutical industry, maintaining consistent quality in multi-particulate capsules is crucial for ensuring therapeutic efficacy and patient safety. Multi-particulate capsules offer numerous advantages, such as targeted drug delivery, controlled release profiles, and improved bioavailability. However, the complexity…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms