Tag: Capsule stability studies

Difficulty in Formulating High-Dose Drugs into Capsule Dosage Forms Overcoming the Challenges in Formulating High-Dose Drugs into Capsule Dosage Forms Context Formulating high-dose drugs into capsule dosage forms presents a significant challenge in the pharmaceutical industry. High-dose drugs require a large volume of excipients to achieve the desired dose, and fitting such a large amount…

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Issues with Compatibility Between Fillers and Active Ingredients Addressing Compatibility Issues Between Fillers and Active Ingredients in Capsule Formulations Context Compatibility between fillers (excipients) and active pharmaceutical ingredients (APIs) is a crucial consideration in the formulation of capsules. Incompatible fillers can lead to various problems, including reduced drug stability, inconsistent drug release, or even degradation…

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Limited Formulation Options for Drugs with Extreme pH Sensitivity Addressing Limited Formulation Options for Drugs with Extreme pH Sensitivity in Capsules Context Drugs with extreme pH sensitivity pose significant challenges in capsule formulation. The solubility, stability, and bioavailability of such drugs are highly dependent on the pH of the gastrointestinal (GI) tract. The acidic environment…

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Challenges in Achieving the Desired Dissolution Profile for Poorly Soluble Drugs Overcoming the Challenges in Achieving the Desired Dissolution Profile for Poorly Soluble Drugs in Capsule Formulations Context Achieving the desired dissolution profile for poorly soluble drugs is a significant challenge in the development of capsule formulations. Poor solubility can lead to reduced bioavailability, inconsistent…

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Drug Stability Issues Due to Interaction with Gelatin Shell Components Addressing Drug Stability Issues Caused by Interaction with Gelatin Capsule Shell Components Context Drug stability is a critical consideration in the manufacturing of soft gelatin capsules, especially when the capsule shell material itself, gelatin, interacts with the active pharmaceutical ingredients (APIs) within the capsule. These…

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Limited Options for Solvents Suitable for Soft Gelatin Capsules Overcoming the Challenge of Limited Solvent Options for Soft Gelatin Capsules Context In pharmaceutical dosage form manufacturing, one of the challenges faced in the production of soft gelatin capsules is selecting the right solvent for dissolving or suspending the active pharmaceutical ingredient (API). The solvents used…

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Sensitivity of the Drug to Moisture Affecting Capsule Integrity How Moisture Sensitivity of Drugs Affects Capsule Integrity and Solutions to Overcome It Context Moisture sensitivity of active pharmaceutical ingredients (APIs) can lead to significant challenges in capsule dosage form manufacturing, especially in soft gelatin capsules. Moisture absorption can compromise the structural integrity of the gelatin…

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Incompatibility of Active Ingredients with Gelatin Shell Materials Addressing the Incompatibility Between Active Ingredients and Gelatin Shell Materials in Capsules Context In the pharmaceutical industry, the incompatibility between active pharmaceutical ingredients (APIs) and gelatin shell materials is a significant challenge in capsule formulation. This issue typically arises in the production of soft gelatin capsules, where…

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Difficulty in Achieving Uniform Drug Distribution within Capsule Fill Material Challenges in Ensuring Uniform Drug Distribution in Capsule Fill Material Context In pharmaceutical dosage form manufacturing, particularly during capsule filling, uniform drug distribution is a critical issue. This problem is encountered during the formulation of both hard and soft gelatin capsules, where ensuring consistent drug…

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