Tag: capsule stability

Problems with maintaining consistent capsule transparency over time.

May 1, 2025 Admin

Problems with maintaining consistent capsule transparency over time. Problems with maintaining consistent capsule transparency over time. Introduction: In the pharmaceutical industry, the appearance of a capsule is not merely an aesthetic concern but a critical quality attribute. Transparency in capsules, especially those made from gelatin, is vital for consumer trust and product acceptance. Over time,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in predicting the impact of high humidity on capsule disintegration times.

April 30, 2025 Admin

Challenges in predicting the impact of high humidity on capsule disintegration times. Challenges in predicting the impact of high humidity on capsule disintegration times. Introduction: In the realm of pharmaceutical manufacturing, ensuring the efficacy and stability of solid oral dosage forms such as capsules is paramount. Capsules, both hard and soft gelatin, are a prevalent…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Lack of validated methods for testing capsule coatings.

April 29, 2025 Admin

Lack of validated methods for testing capsule coatings. Lack of validated methods for testing capsule coatings. Introduction: The pharmaceutical industry relies heavily on solid oral dosage forms, particularly capsules, for drug delivery. Capsules, whether hard or soft gelatin, often require coatings to enhance stability, control release, or mask taste. However, a critical gap persists in…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating nitrogen purity for capsule storage conditions.

April 29, 2025 Admin

Challenges in validating nitrogen purity for capsule storage conditions. Challenges in validating nitrogen purity for capsule storage conditions. Introduction: In the pharmaceutical industry, maintaining the integrity and stability of solid oral dosage forms such as capsules is paramount. The use of nitrogen as an inert gas in storage environments plays a crucial role in preserving…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in predicting the impact of packaging material permeability on capsule stability.

April 28, 2025 Admin

Challenges in predicting the impact of packaging material permeability on capsule stability. Challenges in predicting the impact of packaging material permeability on capsule stability. Introduction: In the pharmaceutical industry, ensuring the stability of capsules—whether hard or soft gelatin—is a critical component of the drug development process. Packaging plays a pivotal role in preserving the integrity…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in assessing the stability of capsules containing biological APIs.

April 27, 2025 Admin

Challenges in assessing the stability of capsules containing biological APIs. Challenges in assessing the stability of capsules containing biological APIs. Introduction: The pharmaceutical industry is increasingly focusing on the development of capsules containing biological Active Pharmaceutical Ingredients (APIs) due to their potential in treating various complex diseases. However, ensuring the stability of these capsules poses…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate control of environmental humidity during soft gelatin production

April 25, 2025 Admin

Inadequate control of environmental humidity during soft gelatin production Inadequate Control of Environmental Humidity During Soft Gelatin Production Introduction: Soft gelatin capsules are a popular dosage form in the pharmaceutical industry, valued for their ability to encapsulate liquid or semi-solid formulations, offering improved bioavailability and patient compliance. However, the production of these capsules is highly…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for monitoring capsule storage equipment performance.

April 25, 2025 Admin

Inadequate systems for monitoring capsule storage equipment performance. Inadequate systems for monitoring capsule storage equipment performance. Introduction: In the pharmaceutical industry, maintaining the integrity and efficacy of solid oral dosage forms, such as capsules, is paramount. Proper storage is essential to ensure that these products remain safe and effective until they reach the end-user. However,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in evaluating stability of capsules with high oil content.

April 24, 2025 Admin

Difficulty in evaluating stability of capsules with high oil content. Difficulty in Evaluating Stability of Capsules with High Oil Content Introduction: In the pharmaceutical industry, capsules are a popular solid oral dosage form, prized for their ease of use and ability to encapsulate both solid and liquid forms. However, when it comes to capsules with…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in dissolution profiles for lipid-based capsules.

April 24, 2025 Admin

Poor reproducibility in dissolution profiles for lipid-based capsules. Poor reproducibility in dissolution profiles for lipid-based capsules. Introduction: Lipid-based capsules, encompassing both hard and soft gelatin varieties, are critical in the delivery of poorly water-soluble drugs. These formulations improve bioavailability, allowing for efficient drug release and absorption. However, achieving consistent dissolution profiles in lipid-based capsules poses…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring compliance with capsule-specific pharmacopeial standards.

April 24, 2025 Admin

Difficulty in ensuring compliance with capsule-specific pharmacopeial standards. Difficulty in ensuring compliance with capsule-specific pharmacopeial standards. Introduction: In the pharmaceutical industry, ensuring compliance with pharmacopeial standards is crucial for the safety and efficacy of drug products. Capsules, both hard and soft gelatin varieties, are a popular dosage form due to their convenience and ability to…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of capsule integrity under stressed storage conditions.

April 24, 2025 Admin

Poor validation of capsule integrity under stressed storage conditions. Poor validation of capsule integrity under stressed storage conditions. Introduction: In the pharmaceutical industry, the integrity of capsules, whether hard or soft gelatin, is paramount to ensure their efficacy, safety, and quality. Capsules are a popular solid oral dosage form due to their ease of use…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms