Tag: Capsule Quality Control

Uneven Distribution of Low-Dose Drugs in the Powder Blend Addressing the Issue of Uneven Distribution of Low-Dose Drugs in the Powder Blend for Capsule Formulations Context Uneven distribution of low-dose drugs in powder blends is a common challenge faced during the formulation of capsule dosage forms. Achieving a uniform blend of the active pharmaceutical ingredient…

Read More “Uneven Distribution of Low-Dose Drugs in the Powder Blend” »

Development Challenges for Fixed-Dose Combination Products Overcoming the Development Challenges for Fixed-Dose Combination Products in Capsules Context Fixed-dose combination (FDC) products are commonly used in pharmaceutical formulations to improve patient adherence and optimize therapeutic outcomes. However, developing these products, especially in capsule form, presents unique challenges. FDCs involve combining two or more active pharmaceutical ingredients…

Read More “Development Challenges for Fixed-Dose Combination Products” »

Problems with Low Drug Loading in Soft Gelatin Capsules Addressing the Challenges of Low Drug Loading in Soft Gelatin Capsules Context Low drug loading in soft gelatin capsules is a significant challenge in pharmaceutical formulation, especially when working with drugs that require high precision in dosage. Low drug loading refers to the inability to incorporate…

Read More “Problems with Low Drug Loading in Soft Gelatin Capsules” »

Difficulty in Formulating High-Dose Drugs into Capsule Dosage Forms Overcoming the Challenges in Formulating High-Dose Drugs into Capsule Dosage Forms Context Formulating high-dose drugs into capsule dosage forms presents a significant challenge in the pharmaceutical industry. High-dose drugs require a large volume of excipients to achieve the desired dose, and fitting such a large amount…

Read More “Difficulty in Formulating High-Dose Drugs into Capsule Dosage Forms” »

Issues with Compatibility Between Fillers and Active Ingredients Addressing Compatibility Issues Between Fillers and Active Ingredients in Capsule Formulations Context Compatibility between fillers (excipients) and active pharmaceutical ingredients (APIs) is a crucial consideration in the formulation of capsules. Incompatible fillers can lead to various problems, including reduced drug stability, inconsistent drug release, or even degradation…

Read More “Issues with Compatibility Between Fillers and Active Ingredients” »

Limited Formulation Options for Drugs with Extreme pH Sensitivity Addressing Limited Formulation Options for Drugs with Extreme pH Sensitivity in Capsules Context Drugs with extreme pH sensitivity pose significant challenges in capsule formulation. The solubility, stability, and bioavailability of such drugs are highly dependent on the pH of the gastrointestinal (GI) tract. The acidic environment…

Read More “Limited Formulation Options for Drugs with Extreme pH Sensitivity” »

Challenges in Achieving the Desired Dissolution Profile for Poorly Soluble Drugs Overcoming the Challenges in Achieving the Desired Dissolution Profile for Poorly Soluble Drugs in Capsule Formulations Context Achieving the desired dissolution profile for poorly soluble drugs is a significant challenge in the development of capsule formulations. Poor solubility can lead to reduced bioavailability, inconsistent…

Read More “Challenges in Achieving the Desired Dissolution Profile for Poorly Soluble Drugs” »

Drug Stability Issues Due to Interaction with Gelatin Shell Components Addressing Drug Stability Issues Caused by Interaction with Gelatin Capsule Shell Components Context Drug stability is a critical consideration in the manufacturing of soft gelatin capsules, especially when the capsule shell material itself, gelatin, interacts with the active pharmaceutical ingredients (APIs) within the capsule. These…

Read More “Drug Stability Issues Due to Interaction with Gelatin Shell Components” »

Limited Options for Solvents Suitable for Soft Gelatin Capsules Overcoming the Challenge of Limited Solvent Options for Soft Gelatin Capsules Context In pharmaceutical dosage form manufacturing, one of the challenges faced in the production of soft gelatin capsules is selecting the right solvent for dissolving or suspending the active pharmaceutical ingredient (API). The solvents used…

Read More “Limited Options for Solvents Suitable for Soft Gelatin Capsules” »