Tag: Capsule Production

Poor validation of capsule weight variation for oil-based fills.

March 10, 2025 Admin

Poor validation of capsule weight variation for oil-based fills. Poor validation of capsule weight variation for oil-based fills Introduction: In the pharmaceutical industry, the production of capsules, especially those containing oil-based fills, presents unique challenges. Capsules are a preferred solid oral dosage form due to their versatility and ability to deliver precise doses of medication….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with ensuring consistent cleaning of high-speed capsule filling machines.

March 10, 2025 Admin

Problems with ensuring consistent cleaning of high-speed capsule filling machines. Problems with ensuring consistent cleaning of high-speed capsule filling machines. Introduction: In the pharmaceutical industry, ensuring the consistent cleaning of high-speed capsule filling machines is crucial for maintaining product quality and safety. These machines play a vital role in the production of both hard and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

High rejection rates due to brittleness in capsule shells after stability testing.

March 10, 2025 Admin

High rejection rates due to brittleness in capsule shells after stability testing. High rejection rates due to brittleness in capsule shells after stability testing. Introduction: The pharmaceutical industry is ever-evolving, with a constant push towards enhancing the quality and efficacy of drug delivery systems. Capsules, both hard and soft gelatin, play a pivotal role in…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in detecting shell cracks during high-speed manufacturing.

March 9, 2025 Admin

Difficulty in detecting shell cracks during high-speed manufacturing. Difficulty in detecting shell cracks during high-speed manufacturing. Introduction: Capsules, both hard and soft gelatin, are among the most popular solid oral dosage forms in the pharmaceutical industry. Their wide acceptance is due to their versatility in delivering a variety of active pharmaceutical ingredients (APIs). However, the…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with maintaining consistent pack weight across different batch sizes.

March 9, 2025 Admin

Problems with maintaining consistent pack weight across different batch sizes. Problems with maintaining consistent pack weight across different batch sizes. Introduction: In the pharmaceutical industry, maintaining consistent pack weight across different batch sizes is crucial for ensuring the efficacy, safety, and quality of solid oral dosage forms like capsules. Variations in pack weight can lead…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for monitoring capsule integrity during validation.

March 9, 2025 Admin

Inadequate systems for monitoring capsule integrity during validation. Inadequate Systems for Monitoring Capsule Integrity During Validation Introduction: In the pharmaceutical industry, the integrity of capsules, whether hard or soft gelatin, is crucial for ensuring the efficacy and safety of the medication contained within. Monitoring capsule integrity during validation is an essential part of the manufacturing…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating nitrogen distribution systems for soft capsule drying.

March 8, 2025 Admin

Challenges in validating nitrogen distribution systems for soft capsule drying. Challenges in validating nitrogen distribution systems for soft capsule drying. Introduction: In the pharmaceutical industry, the production of soft gelatin capsules is a complex process that requires precise conditions to ensure product quality and efficacy. One critical aspect of this process is the drying phase,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule sealing for capsules with multi-layer fills.

March 8, 2025 Admin

Difficulty in validating capsule sealing for capsules with multi-layer fills. Difficulty in validating capsule sealing for capsules with multi-layer fills Introduction: Capsules have long been a preferred dosage form in the pharmaceutical industry due to their versatility and convenience. The advent of multi-layer fills in capsules has paved the way for innovative drug delivery systems….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule orientation devices for automated filling lines.

March 8, 2025 Admin

Difficulty in validating capsule orientation devices for automated filling lines. Difficulty in Validating Capsule Orientation Devices for Automated Filling Lines Introduction: In the pharmaceutical industry, the production of solid oral dosage forms such as capsules plays a crucial role. Capsules, whether hard or soft gelatin, are highly favored due to their ease of administration and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring consistent gelatin solution cooling rates.

March 7, 2025 Admin

Difficulty in ensuring consistent gelatin solution cooling rates. Difficulty in ensuring consistent gelatin solution cooling rates. Introduction: Gelatin capsules, both hard and soft, are a vital part of the pharmaceutical landscape. Their popularity stems from their ability to encapsulate a wide range of formulations, offering precise dosage and bioavailability. However, one of the critical aspects…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with validating capsule weight variation for hard gelatin capsules.

March 7, 2025 Admin

Problems with validating capsule weight variation for hard gelatin capsules. Problems with validating capsule weight variation for hard gelatin capsules. Introduction: In the pharmaceutical industry, hard gelatin capsules are a prevalent form of solid oral dosage. Ensuring the consistency of capsule weight is crucial for maintaining dosage accuracy, therapeutic efficacy, and patient safety. Variations in…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for monitoring gelatin solution viscosity during validation.

March 6, 2025 Admin

Inadequate systems for monitoring gelatin solution viscosity during validation. Inadequate systems for monitoring gelatin solution viscosity during validation. Introduction: In the pharmaceutical industry, ensuring the quality and consistency of solid oral dosage forms is crucial. Gelatin capsules, both hard and soft, are popular due to their ease of use and ability to encapsulate a variety…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms