Tag: Capsule formulation

Problems with validating capsule sealing for capsules with delayed-release profiles.

April 3, 2025 Admin

Problems with validating capsule sealing for capsules with delayed-release profiles. Problems with Validating Capsule Sealing for Capsules with Delayed-Release Profiles Introduction: In the pharmaceutical industry, the demand for delayed-release capsules has been on the rise due to their ability to deliver active ingredients at specific sites within the gastrointestinal tract. These capsules are crucial for…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with maintaining uniform gelatin shell thickness.

April 2, 2025 Admin

Problems with maintaining uniform gelatin shell thickness. Problems with maintaining uniform gelatin shell thickness. Introduction: In the world of pharmaceutical manufacturing, ensuring the uniformity of gelatin shell thickness in capsules is pivotal. Uniform gelatin shells not only guarantee the integrity and reliability of the dosage form but also ensure patient safety and efficacy of the…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Lack of validated protocols for testing highly hydrophobic APIs.

April 2, 2025 Admin

Lack of validated protocols for testing highly hydrophobic APIs. Lack of validated protocols for testing highly hydrophobic APIs. Introduction: In the pharmaceutical industry, the development and testing of Active Pharmaceutical Ingredients (APIs) are crucial for ensuring drug efficacy and safety. However, one significant challenge that researchers and formulators face is dealing with highly hydrophobic APIs,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in conducting root cause analysis for capsule quality failures.

April 2, 2025 Admin

Difficulty in conducting root cause analysis for capsule quality failures. Difficulty in conducting root cause analysis for capsule quality failures. Introduction: The pharmaceutical industry is tasked with the critical responsibility of ensuring that all medicinal products are safe, effective, and of the highest quality. Capsules, both hard and soft gelatin, are among the most common…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in vacuum sealing of capsule containers.

April 1, 2025 Admin

Poor reproducibility in vacuum sealing of capsule containers. Poor Reproducibility in Vacuum Sealing of Capsule Containers Introduction: In the pharmaceutical industry, ensuring the integrity and stability of capsule packaging is crucial. Capsules, whether hard or soft gelatin, are sensitive to environmental factors such as moisture and oxygen, which can compromise their efficacy and shelf life….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating the performance of capsule filling equipment.

April 1, 2025 Admin

Challenges in validating the performance of capsule filling equipment. Challenges in validating the performance of capsule filling equipment. Introduction: In the pharmaceutical industry, capsule filling equipment plays a crucial role in the production of solid oral dosage forms. These machines are responsible for accurately filling hard and soft gelatin capsules with the appropriate dosage of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate methods for detecting trace levels of insoluble residues.

April 1, 2025 Admin

Inadequate methods for detecting trace levels of insoluble residues. Inadequate Methods for Detecting Trace Levels of Insoluble Residues Introduction: In the pharmaceutical industry, the integrity and purity of drug products are paramount. Particularly with solid oral dosage forms, such as capsules, ensuring that no insoluble residues remain is critical for both efficacy and patient safety….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in gelatin elasticity data under various storage conditions.

March 31, 2025 Admin

Poor reproducibility in gelatin elasticity data under various storage conditions. Poor reproducibility in gelatin elasticity data under various storage conditions. Introduction: Gelatin capsules, both hard and soft gelatin, are pivotal in the pharmaceutical industry as they offer a stable and effective medium for drug delivery. However, the elasticity of gelatin, a critical factor in capsule…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in assessing stability of capsules containing hygroscopic excipients.

March 28, 2025 Admin

Difficulty in assessing stability of capsules containing hygroscopic excipients. Difficulty in Assessing Stability of Capsules Containing Hygroscopic Excipients Introduction: In the pharmaceutical industry, the stability of drug formulations is paramount to ensuring efficacy and safety. Capsules, both hard and soft gelatin, are popular solid oral dosage forms due to their convenience and patient compliance. However,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in maintaining consistent capsule integrity during high-speed packing.

March 25, 2025 Admin

Difficulty in maintaining consistent capsule integrity during high-speed packing. Difficulty in maintaining consistent capsule integrity during high-speed packing. Introduction: In the fast-paced world of pharmaceutical manufacturing, maintaining consistent capsule integrity during high-speed packing can pose significant challenges. Capsules, whether hard or soft gelatin, are popular solid oral dosage forms due to their ease of administration…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate validation of capsule performance under variable storage conditions.

March 22, 2025 Admin

Inadequate validation of capsule performance under variable storage conditions. Inadequate validation of capsule performance under variable storage conditions Introduction: In the pharmaceutical industry, ensuring the stability and performance of dosage forms, such as capsules, under varying storage conditions is crucial. Capsules, whether hard or soft gelatin, are popular for their ease of administration and ability…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with ensuring consistent nitrogen distribution for capsule production.

March 21, 2025 Admin

Problems with ensuring consistent nitrogen distribution for capsule production. Problems with ensuring consistent nitrogen distribution for capsule production. Introduction: In the pharmaceutical industry, the production of solid oral dosage forms such as capsules is a complex process that requires meticulous attention to detail. Among the various factors that influence capsule quality, the consistent distribution of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms