Tag: Capsule formulation

Poor validation of capsule disintegration profiles for capsules stored under stressed conditions.

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Poor validation of capsule disintegration profiles for capsules stored under stressed conditions. Poor validation of capsule disintegration profiles for capsules stored under stressed conditions. Introduction: In the pharmaceutical industry, ensuring the effective disintegration of capsules is crucial for the drug’s efficacy and safety. Disintegration testing is an essential quality control measure that determines whether capsules…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

High rejection rates due to improperly filled capsule packs.

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High rejection rates due to improperly filled capsule packs. High Rejection Rates Due to Improperly Filled Capsule Packs Introduction: In the pharmaceutical industry, solid oral dosage forms such as capsules are a cornerstone due to their convenience and efficacy in delivering medication. However, the integrity of capsule packs is paramount to ensure patient safety and…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with ensuring proper cleaning of capsule weighing systems.

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Problems with ensuring proper cleaning of capsule weighing systems. Problems with Ensuring Proper Cleaning of Capsule Weighing Systems Introduction: In the pharmaceutical industry, maintaining the cleanliness of equipment is pivotal to ensuring product safety, efficacy, and quality. One critical aspect of this is the cleaning of capsule weighing systems used in the manufacturing of solid…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with validating capsule drying processes for low-humidity environments.

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Problems with validating capsule drying processes for low-humidity environments. Problems with validating capsule drying processes for low-humidity environments. Introduction: In the realm of pharmaceutical manufacturing, capsules serve as one of the most popular solid oral dosage forms due to their versatility and patient compliance. However, the process of drying capsules, particularly in low-humidity environments, presents…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for validating capsule drying profiles for soft gelatin capsules.

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Inadequate systems for validating capsule drying profiles for soft gelatin capsules. Inadequate systems for validating capsule drying profiles for soft gelatin capsules. Introduction: Soft gelatin capsules are a popular dosage form in the pharmaceutical industry due to their versatility in encapsulating a wide range of substances, including liquids, suspensions, and semi-solids. Ensuring the proper drying…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for detecting powder segregation during mixing.

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Inadequate systems for detecting powder segregation during mixing. Inadequate Systems for Detecting Powder Segregation During Mixing Introduction: In the pharmaceutical industry, ensuring the homogeneity of powder mixtures is crucial for the consistency and efficacy of solid oral dosage forms, particularly capsules. Powder segregation during mixing can lead to significant quality control issues, impacting the uniformity…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with ensuring consistent gelatin plasticizer levels over storage periods.

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Problems with ensuring consistent gelatin plasticizer levels over storage periods. Problems with ensuring consistent gelatin plasticizer levels over storage periods. Introduction: Gelatin capsules, both hard and soft, are a cornerstone of pharmaceutical dosage forms due to their ease of ingestion and ability to encapsulate a wide variety of substances. A critical component in the manufacturing…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with detecting microscopic cracks in gelatin shells.

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Problems with detecting microscopic cracks in gelatin shells. Problems with Detecting Microscopic Cracks in Gelatin Shells Introduction: Gelatin capsules, both hard and soft, are integral to the pharmaceutical industry due to their effectiveness in encapsulating drugs and providing controlled release. However, ensuring the integrity of these capsules is critical, as even microscopic cracks in the…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with achieving consistent shell thickness for multi-particulate capsules.

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Problems with achieving consistent shell thickness for multi-particulate capsules. Problems with achieving consistent shell thickness for multi-particulate capsules. Introduction: In the pharmaceutical industry, the production of multi-particulate capsules has become increasingly significant due to their advantages in controlled drug release and patient compliance. However, achieving consistent shell thickness in these capsules is crucial for ensuring…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule filling processes for powders with variable particle size.

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Difficulty in validating capsule filling processes for powders with variable particle size. Difficulty in Validating Capsule Filling Processes for Powders with Variable Particle Size Introduction: In the pharmaceutical industry, capsules are one of the most common forms of solid oral dosage. They offer numerous advantages, including ease of swallowing, better taste masking, and precise dosage….

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with predicting the stability of capsules containing sensitive APIs.

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Problems with predicting the stability of capsules containing sensitive APIs. Problems with Predicting the Stability of Capsules Containing Sensitive APIs Introduction: In the pharmaceutical industry, ensuring the stability of drug products is paramount to maintaining efficacy and safety throughout their shelf life. Capsules, both hard and soft gelatin, are popular dosage forms due to their…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating capsule drying equipment for dual-layer formulations.

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Challenges in validating capsule drying equipment for dual-layer formulations. Challenges in validating capsule drying equipment for dual-layer formulations. Introduction: In the realm of pharmaceutical manufacturing, the development and validation of dual-layer formulations present unique challenges, particularly in the drying stage of capsule production. The drying process is critical to ensuring the stability, efficacy, and safety…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms