Tag: Capsule formulation

High variability in sealing strength for capsule containers.

April 19, 2025 Admin

High variability in sealing strength for capsule containers. High variability in sealing strength for capsule containers. Introduction: In the pharmaceutical industry, ensuring the quality and integrity of solid oral dosage forms is paramount. Capsule containers, especially hard and soft gelatin capsules, are widely used due to their convenience and efficiency in drug delivery. However, one…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with validating capsule release testing equipment.

April 19, 2025 Admin

Problems with validating capsule release testing equipment. Problems with Validating Capsule Release Testing Equipment Introduction: In the pharmaceutical industry, ensuring the consistent and reliable release of active pharmaceutical ingredients (APIs) from capsules is crucial for therapeutic efficacy. Capsule release testing, also known as dissolution testing, is a critical quality control process used to evaluate the…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor oversight of third-party vendors supplying capsule shells.

April 18, 2025 Admin

Poor oversight of third-party vendors supplying capsule shells. Poor Oversight of Third-Party Vendors Supplying Capsule Shells Introduction: In the pharmaceutical industry, ensuring the quality and safety of solid oral dosage forms, such as capsules, is paramount. Capsules, whether hard or soft gelatin, serve as vital delivery vehicles for medications. However, the integrity of these capsules…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with ensuring consistent capsule dimensions across batches.

April 18, 2025 Admin

Problems with ensuring consistent capsule dimensions across batches. Problems with ensuring consistent capsule dimensions across batches. Introduction: In the pharmaceutical industry, the consistency of capsule dimensions is a crucial quality attribute that ensures the safety, efficacy, and reliability of the medication. Capsules, both hard and soft gelatin, are a preferred dosage form due to their…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in assessing stability of capsules with non-aqueous fills.

April 18, 2025 Admin

Challenges in assessing stability of capsules with non-aqueous fills. Challenges in assessing stability of capsules with non-aqueous fills. Introduction: In the pharmaceutical industry, ensuring the stability of drug products is crucial for maintaining efficacy and safety. Capsules, both hard and soft gelatin, are popular solid oral dosage forms. However, when these capsules are filled with…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate monitoring systems for capsule shell flexibility.

April 18, 2025 Admin

Inadequate monitoring systems for capsule shell flexibility. Inadequate Monitoring Systems for Capsule Shell Flexibility Introduction: In the pharmaceutical industry, capsules, especially gelatin-based ones, are a prevalent dosage form due to their ease of use and ability to encapsulate both solid and liquid formulations. However, ensuring the flexibility and integrity of these capsule shells is crucial…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of analytical methods for capsule testing.

April 18, 2025 Admin

Poor validation of analytical methods for capsule testing. Poor validation of analytical methods for capsule testing. Introduction: The validation of analytical methods is a critical component of pharmaceutical development and manufacturing, especially for solid oral dosage forms like capsules. Both hard and soft gelatin capsules require precise and reliable analytical methods to ensure their safety,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in maintaining consistent quality for multi-particulate capsules.

April 18, 2025 Admin

Challenges in maintaining consistent quality for multi-particulate capsules. Challenges in maintaining consistent quality for multi-particulate capsules. Introduction: In the pharmaceutical industry, maintaining consistent quality in multi-particulate capsules is crucial for ensuring therapeutic efficacy and patient safety. Multi-particulate capsules offer numerous advantages, such as targeted drug delivery, controlled release profiles, and improved bioavailability. However, the complexity…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in detecting cross-linking of gelatin in hard capsules.

April 17, 2025 Admin

Challenges in detecting cross-linking of gelatin in hard capsules. Challenges in detecting cross-linking of gelatin in hard capsules. Introduction: Gelatin capsules, especially hard gelatin capsules, are a cornerstone in the pharmaceutical industry, prized for their versatility and efficiency in delivering medications. However, one significant challenge that can impact their performance is gelatin cross-linking. This chemical…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in maintaining consistent capsule weight variation during validation.

April 17, 2025 Admin

Challenges in maintaining consistent capsule weight variation during validation. Challenges in Maintaining Consistent Capsule Weight Variation During Validation Introduction: In the pharmaceutical industry, maintaining consistent capsule weight variation is critical during the validation phase of capsule production. This process ensures that each capsule contains the correct amount of active pharmaceutical ingredient (API), providing efficacy and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in maintaining consistent capsule hardness over the stability period.

April 17, 2025 Admin

Difficulty in maintaining consistent capsule hardness over the stability period. Difficulty in maintaining consistent capsule hardness over the stability period. Introduction: Capsules, both hard and soft gelatin, are a prevalent form of oral dosage in the pharmaceutical industry due to their versatility and patient compliance. However, maintaining consistent hardness throughout the stability period is a…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate validation of capsule performance under freezing conditions.

April 16, 2025 Admin

Inadequate validation of capsule performance under freezing conditions. Inadequate validation of capsule performance under freezing conditions Introduction: In the pharmaceutical industry, solid oral dosage forms like capsules are a popular choice due to their convenience, stability, and patient compliance. However, the performance of capsules under various environmental conditions, especially freezing conditions, can be a significant…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms