Tag: Capsule formulation

Challenges in achieving uniform capsule transparency during validation.

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Challenges in achieving uniform capsule transparency during validation. Challenges in achieving uniform capsule transparency during validation. Introduction: In the pharmaceutical industry, the demand for consistent and high-quality solid oral dosage forms has never been greater. Among these, capsules, particularly hard and soft gelatin capsules, stand out due to their versatility and consumer preference for ease…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in dissolution testing results for capsules stored under stressed conditions.

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Poor reproducibility in dissolution testing results for capsules stored under stressed conditions. Poor reproducibility in dissolution testing results for capsules stored under stressed conditions. Introduction: Dissolution testing is a critical quality control procedure in the pharmaceutical industry, especially for solid oral dosage forms such as capsules. It ensures that the drug releases at the intended…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with maintaining consistent capsule transparency over time.

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Problems with maintaining consistent capsule transparency over time. Problems with maintaining consistent capsule transparency over time. Introduction: In the pharmaceutical industry, the appearance of a capsule is not merely an aesthetic concern but a critical quality attribute. Transparency in capsules, especially those made from gelatin, is vital for consumer trust and product acceptance. Over time,…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

High rejection rates due to improper alignment of capsule compartments.

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High rejection rates due to improper alignment of capsule compartments. High Rejection Rates Due to Improper Alignment of Capsule Compartments Introduction: In the pharmaceutical industry, the production of solid oral dosage forms, particularly capsules, is a critical process that requires precision and accuracy. Capsules, whether hard or soft gelatin, are a popular choice for delivering…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in predicting the impact of high humidity on capsule disintegration times.

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Challenges in predicting the impact of high humidity on capsule disintegration times. Challenges in predicting the impact of high humidity on capsule disintegration times. Introduction: In the realm of pharmaceutical manufacturing, ensuring the efficacy and stability of solid oral dosage forms such as capsules is paramount. Capsules, both hard and soft gelatin, are a prevalent…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Lack of validated methods for testing capsule coatings.

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Lack of validated methods for testing capsule coatings. Lack of validated methods for testing capsule coatings. Introduction: The pharmaceutical industry relies heavily on solid oral dosage forms, particularly capsules, for drug delivery. Capsules, whether hard or soft gelatin, often require coatings to enhance stability, control release, or mask taste. However, a critical gap persists in…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring consistent gelatin viscosity during preparation.

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Difficulty in ensuring consistent gelatin viscosity during preparation. Difficulty in Ensuring Consistent Gelatin Viscosity During Preparation Introduction: In the pharmaceutical industry, ensuring the consistent viscosity of gelatin during the preparation of capsules is crucial. Gelatin is a key component in both hard and soft gelatin capsules, which are popular solid oral dosage forms due to…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in predicting the impact of packaging material permeability on capsule stability.

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Challenges in predicting the impact of packaging material permeability on capsule stability. Challenges in predicting the impact of packaging material permeability on capsule stability. Introduction: In the pharmaceutical industry, ensuring the stability of capsules—whether hard or soft gelatin—is a critical component of the drug development process. Packaging plays a pivotal role in preserving the integrity…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate control over capsule component traceability.

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Inadequate control over capsule component traceability. Inadequate control over capsule component traceability. Introduction: In the pharmaceutical industry, ensuring the traceability of capsule components is crucial for maintaining product quality, ensuring patient safety, and complying with regulatory standards. Traceability refers to the ability to track every ingredient and material used in the manufacturing of capsules, from…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for verifying cleaning effectiveness for gelatin-free formulations.

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Inadequate systems for verifying cleaning effectiveness for gelatin-free formulations. Inadequate systems for verifying cleaning effectiveness for gelatin-free formulations. Introduction: In the pharmaceutical industry, ensuring the cleaning effectiveness of manufacturing equipment is critical, especially when producing gelatin-free formulations. Such formulations represent a growing trend due to dietary preferences, allergies, and religious beliefs. However, the absence of…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating nitrogen purity levels for capsule drying processes.

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Challenges in validating nitrogen purity levels for capsule drying processes. Challenges in Validating Nitrogen Purity Levels for Capsule Drying Processes Introduction: In the pharmaceutical industry, maintaining the quality and integrity of solid oral dosage forms, such as capsules, is paramount. The drying process of capsules, whether hard or soft gelatin, is a critical step that…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in evaluating stability of capsules with high oil content.

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Difficulty in evaluating stability of capsules with high oil content. Difficulty in Evaluating Stability of Capsules with High Oil Content Introduction: In the pharmaceutical industry, capsules are a popular solid oral dosage form, prized for their ease of use and ability to encapsulate both solid and liquid forms. However, when it comes to capsules with…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms