Tag: Capsule dissolution testing

Limited Options for Solvents Suitable for Soft Gelatin Capsules Overcoming the Challenge of Limited Solvent Options for Soft Gelatin Capsules Context In pharmaceutical dosage form manufacturing, one of the challenges faced in the production of soft gelatin capsules is selecting the right solvent for dissolving or suspending the active pharmaceutical ingredient (API). The solvents used…

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Sensitivity of the Drug to Moisture Affecting Capsule Integrity How Moisture Sensitivity of Drugs Affects Capsule Integrity and Solutions to Overcome It Context Moisture sensitivity of active pharmaceutical ingredients (APIs) can lead to significant challenges in capsule dosage form manufacturing, especially in soft gelatin capsules. Moisture absorption can compromise the structural integrity of the gelatin…

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Incompatibility of Active Ingredients with Gelatin Shell Materials Addressing the Incompatibility Between Active Ingredients and Gelatin Shell Materials in Capsules Context In the pharmaceutical industry, the incompatibility between active pharmaceutical ingredients (APIs) and gelatin shell materials is a significant challenge in capsule formulation. This issue typically arises in the production of soft gelatin capsules, where…

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Difficulty in Achieving Uniform Drug Distribution within Capsule Fill Material Challenges in Ensuring Uniform Drug Distribution in Capsule Fill Material Context In pharmaceutical dosage form manufacturing, particularly during capsule filling, uniform drug distribution is a critical issue. This problem is encountered during the formulation of both hard and soft gelatin capsules, where ensuring consistent drug…

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