Tag: Capsule brittleness

Poor Reproducibility in Friability Testing of Filled Capsules Addressing Poor Reproducibility in Friability Testing of Filled Capsules Context Friability testing is an essential quality control test used to assess the…

High Operator Dependency in Manual Testing Methods Addressing High Operator Dependency in Manual Testing Methods Context Manual testing methods are commonly used in pharmaceutical manufacturing and quality control to assess…

Lack of Validated Methods for Lipid-Based Soft Gelatin Capsule Formulations Addressing the Lack of Validated Methods for Lipid-Based Soft Gelatin Capsule Formulations Context Lipid-based soft gelatin capsules are increasingly being…

Problems with Achieving Reliable Results in Weight Variation Tests Addressing Problems with Achieving Reliable Results in Weight Variation Tests Context Weight variation tests are critical for ensuring the uniformity and…

Incompatibility of Certain Capsule Formulations with Common HPLC Solvents Addressing the Incompatibility of Certain Capsule Formulations with Common HPLC Solvents Context High-performance liquid chromatography (HPLC) is a widely used analytical…

Difficulty in Testing Capsules Containing Insoluble APIs Addressing the Difficulty in Testing Capsules Containing Insoluble APIs Context The testing of capsules containing insoluble active pharmaceutical ingredients (APIs) presents a unique…

High Variability in Dissolution Testing Results Due to Inconsistent Agitation Speed Addressing High Variability in Dissolution Testing Results Due to Inconsistent Agitation Speed Context Dissolution testing is an essential process…

Lack of Robust Testing Protocols for Moisture Content in Capsules Addressing the Lack of Robust Testing Protocols for Moisture Content in Capsules Context Moisture content is a critical quality attribute…

Inadequate Sensitivity of Analytical Methods for Detecting Low API Concentrations Addressing the Inadequate Sensitivity of Analytical Methods for Detecting Low API Concentrations Context Low-dose drugs often contain active pharmaceutical ingredients…

Difficulty in Detecting Cross-Linking in Hard Gelatin Capsule Shells Addressing the Difficulty in Detecting Cross-Linking in Hard Gelatin Capsule Shells Context Cross-linking in hard gelatin capsule shells occurs when the…

Poor Reproducibility in Uniformity of Content Testing for Low-Dose Drugs Addressing Poor Reproducibility in Uniformity of Content Testing for Low-Dose Drugs Context Uniformity of content is a critical factor in…

Variability in Capsule Disintegration Times Across Stability Samples Addressing Variability in Capsule Disintegration Times Across Stability Samples Context Disintegration time is a critical quality attribute for oral dosage forms, including…