Tag: Capsule brittleness

Problems with Encapsulating Drugs with Variable Particle Size Distribution Addressing Problems with Encapsulating Drugs with Variable Particle Size Distribution Context The encapsulation of drugs with variable particle size distribution (PSD)…

Lack of Standardization in Lipid-Based Excipient Formulations Addressing the Lack of Standardization in Lipid-Based Excipient Formulations Context Lipid-based excipients, such as oils, fats, and lipids, play a critical role in…

Challenges in Optimizing Shell Composition for Faster Disintegration Addressing the Challenges in Optimizing Shell Composition for Faster Disintegration Context The disintegration time of soft gelatin capsules plays a crucial role…

Difficulty in Encapsulating Oils with High Peroxide Content Addressing the Difficulty in Encapsulating Oils with High Peroxide Content Context Encapsulating oils in soft gelatin capsules is a common practice for…

Problems with Achieving the Required Viscosity for Soft Gelatin Fill Material Addressing Problems with Achieving the Required Viscosity for Soft Gelatin Fill Material Context Achieving the required viscosity for soft…

Incompatibility of High-Shear Granulation Processes with Capsule Formulations Addressing the Incompatibility of High-Shear Granulation Processes with Capsule Formulations Context High-shear granulation is commonly used in the pharmaceutical industry for the…

Issues with Developing Stable Dispersions for Soft Gelatin Capsules Addressing Issues with Developing Stable Dispersions for Soft Gelatin Capsules Context Developing stable dispersions for soft gelatin capsules can be challenging,…

Difficulty in Masking the Unpleasant Odor of Certain APIs Addressing the Difficulty in Masking the Unpleasant Odor of Certain APIs Context The unpleasant odor of certain active pharmaceutical ingredients (APIs)…

Formulation Development Challenges for Pediatric Capsule Dosage Forms Addressing Formulation Development Challenges for Pediatric Capsule Dosage Forms Context Pediatric patients present unique challenges in pharmaceutical formulation, particularly when it comes…

Complexity in Designing Formulations for Site-Specific Drug Release Addressing the Complexity in Designing Formulations for Site-Specific Drug Release Context Site-specific drug release is a challenging but critical aspect of pharmaceutical…

Problems with Capsule Weight Gain During Stability Studies Addressing Problems with Capsule Weight Gain During Stability Studies Context Capsule weight gain during stability studies is a significant challenge in the…

Limited Compatibility of Acid-Sensitive APIs with Hard Gelatin Capsules Addressing the Limited Compatibility of Acid-Sensitive APIs with Hard Gelatin Capsules Context Hard gelatin capsules are commonly used for drug delivery,…