Tag: Capsule brittleness

Drug Stability Issues Due to Interaction with Gelatin Shell Components

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Drug Stability Issues Due to Interaction with Gelatin Shell Components Addressing Drug Stability Issues Caused by Interaction with Gelatin Capsule Shell Components Context Drug stability is a critical consideration in the manufacturing of soft gelatin capsules, especially when the capsule shell material itself, gelatin, interacts with the active pharmaceutical ingredients (APIs) within the capsule. These…

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Capsules (Hard & Soft Gelatin)

Limited Options for Solvents Suitable for Soft Gelatin Capsules

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Limited Options for Solvents Suitable for Soft Gelatin Capsules Overcoming the Challenge of Limited Solvent Options for Soft Gelatin Capsules Context In pharmaceutical dosage form manufacturing, one of the challenges faced in the production of soft gelatin capsules is selecting the right solvent for dissolving or suspending the active pharmaceutical ingredient (API). The solvents used…

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Capsules (Hard & Soft Gelatin)

Sensitivity of the Drug to Moisture Affecting Capsule Integrity

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Sensitivity of the Drug to Moisture Affecting Capsule Integrity How Moisture Sensitivity of Drugs Affects Capsule Integrity and Solutions to Overcome It Context Moisture sensitivity of active pharmaceutical ingredients (APIs) can lead to significant challenges in capsule dosage form manufacturing, especially in soft gelatin capsules. Moisture absorption can compromise the structural integrity of the gelatin…

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Capsules (Hard & Soft Gelatin)

Incompatibility of Active Ingredients with Gelatin Shell Materials

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Incompatibility of Active Ingredients with Gelatin Shell Materials Addressing the Incompatibility Between Active Ingredients and Gelatin Shell Materials in Capsules Context In the pharmaceutical industry, the incompatibility between active pharmaceutical ingredients (APIs) and gelatin shell materials is a significant challenge in capsule formulation. This issue typically arises in the production of soft gelatin capsules, where…

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Capsules (Hard & Soft Gelatin)

Difficulty in Achieving Uniform Drug Distribution within Capsule Fill Material

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Difficulty in Achieving Uniform Drug Distribution within Capsule Fill Material Challenges in Ensuring Uniform Drug Distribution in Capsule Fill Material Context In pharmaceutical dosage form manufacturing, particularly during capsule filling, uniform drug distribution is a critical issue. This problem is encountered during the formulation of both hard and soft gelatin capsules, where ensuring consistent drug…

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Capsules (Hard & Soft Gelatin)

Inadequate monitoring systems for capsule shell flexibility.

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Inadequate monitoring systems for capsule shell flexibility. Inadequate Monitoring Systems for Capsule Shell Flexibility Introduction: In the pharmaceutical industry, capsules, especially gelatin-based ones, are a prevalent dosage form due to their ease of use and ability to encapsulate both solid and liquid formulations. However, ensuring the flexibility and integrity of these capsule shells is crucial…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in distinguishing capsule defects due to environmental effects.

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Difficulty in distinguishing capsule defects due to environmental effects. Difficulty in Distinguishing Capsule Defects Due to Environmental Effects Introduction: Capsules, both hard and soft gelatin, are a prevalent form of solid oral dosage utilized in pharmaceutical products. They offer advantages such as ease of swallowing and the ability to mask unpleasant tastes. However, ensuring their…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with ensuring consistent gelatin plasticizer levels over storage periods.

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Problems with ensuring consistent gelatin plasticizer levels over storage periods. Problems with ensuring consistent gelatin plasticizer levels over storage periods. Introduction: Gelatin capsules, both hard and soft, are a cornerstone of pharmaceutical dosage forms due to their ease of ingestion and ability to encapsulate a wide variety of substances. A critical component in the manufacturing…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in determining the impact of low-temperature storage on capsule shells.

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Challenges in determining the impact of low-temperature storage on capsule shells. Challenges in determining the impact of low-temperature storage on capsule shells. Introduction: The pharmaceutical industry significantly relies on capsules as a solid oral dosage form due to their versatility and effectiveness in delivering active pharmaceutical ingredients (APIs). Capsules, whether hard or soft gelatin, provide…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

High rejection rates due to brittleness in capsule shells after stability testing.

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High rejection rates due to brittleness in capsule shells after stability testing. High rejection rates due to brittleness in capsule shells after stability testing. Introduction: The pharmaceutical industry is ever-evolving, with a constant push towards enhancing the quality and efficacy of drug delivery systems. Capsules, both hard and soft gelatin, play a pivotal role in…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate methods for monitoring capsule brittleness under low humidity conditions.

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Inadequate methods for monitoring capsule brittleness under low humidity conditions. Inadequate Methods for Monitoring Capsule Brittleness Under Low Humidity Conditions Introduction: Capsules, both hard and soft gelatin, are a prevalent form of solid oral dosage forms in the pharmaceutical industry. Ensuring their integrity and efficacy is crucial for therapeutic effectiveness. One of the significant challenges…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in ensuring consistent capsule integrity under stressed conditions.

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Challenges in ensuring consistent capsule integrity under stressed conditions. Challenges in ensuring consistent capsule integrity under stressed conditions. Introduction: Capsules, both hard and soft gelatin, are among the most popular solid oral dosage forms in the pharmaceutical industry due to their ease of administration and ability to encapsulate a wide range of medicinal compounds. However,…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms