Tag: bioavailability

Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing

April 30, 2025 Admin

Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing Introduction: The pharmaceutical industry constantly strives to develop effective drug delivery mechanisms, with enteric-coated tablets serving as a crucial form of solid dosage. These tablets are designed to resist the acidic environment of the stomach, releasing their active ingredients…

Solid Dosage form, Tablets

Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets

April 28, 2025 Admin

Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets Introduction: Coated tablets are a widely used solid dosage form in the pharmaceutical industry, offering benefits such as improved taste masking, controlled drug release, and enhanced stability. However, achieving consistent dissolution profiles is critical as it directly impacts the…

Solid Dosage form, Tablets

Challenges in assessing the stability of capsules containing biological APIs.

April 27, 2025 Admin

Challenges in assessing the stability of capsules containing biological APIs. Challenges in assessing the stability of capsules containing biological APIs. Introduction: The pharmaceutical industry is increasingly focusing on the development of capsules containing biological Active Pharmaceutical Ingredients (APIs) due to their potential in treating various complex diseases. However, ensuring the stability of these capsules poses…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in dissolution profiles for lipid-based capsules.

April 24, 2025 Admin

Poor reproducibility in dissolution profiles for lipid-based capsules. Poor reproducibility in dissolution profiles for lipid-based capsules. Introduction: Lipid-based capsules, encompassing both hard and soft gelatin varieties, are critical in the delivery of poorly water-soluble drugs. These formulations improve bioavailability, allowing for efficient drug release and absorption. However, achieving consistent dissolution profiles in lipid-based capsules poses…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor correlation between in vitro dissolution and stability data.

April 24, 2025 Admin

Poor correlation between in vitro dissolution and stability data. Poor correlation between in vitro dissolution and stability data. Introduction: In the pharmaceutical industry, the correlation between in vitro dissolution and stability data is pivotal for ensuring the efficacy and safety of solid oral dosage forms, particularly capsules. Dissolution testing is a key quality control measure…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Ensuring Adequacy of Binder Distribution in Sustained Release Tablet Validation

April 19, 2025 Admin

Ensuring Adequacy of Binder Distribution in Sustained Release Tablet Validation Ensuring Adequacy of Binder Distribution in Sustained Release Tablet Validation Introduction: In the complex world of pharmaceutical manufacturing, sustained release tablets represent a crucial advancement in medication delivery systems. These tablets offer numerous benefits, including improved patient compliance and enhanced bioavailability. However, the validation of…

Solid Dosage form, Tablets

Poor reproducibility in validation data for modified-release capsules.

April 17, 2025 Admin

Poor reproducibility in validation data for modified-release capsules. Poor reproducibility in validation data for modified-release capsules. Introduction: Modified-release capsules are pivotal in modern therapeutics, offering controlled drug delivery that improves patient compliance and therapeutic outcomes. However, ensuring the reproducibility of validation data for these formulations is crucial in maintaining their efficacy and safety. Inconsistent validation…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for monitoring capsule release profiles.

April 17, 2025 Admin

Inadequate systems for monitoring capsule release profiles. Inadequate systems for monitoring capsule release profiles. Introduction: The pharmaceutical industry is a cornerstone of modern healthcare, where ensuring the efficacy and safety of medications is paramount. Solid oral dosage forms, particularly capsules, play a significant role due to their convenience and patient compliance. However, the inadequacy of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in testing soft gelatin capsules with high oil content.

April 16, 2025 Admin

Challenges in testing soft gelatin capsules with high oil content. Challenges in testing soft gelatin capsules with high oil content Introduction: Soft gelatin capsules are a popular dosage form in the pharmaceutical industry, offering unique advantages such as improved bioavailability and patient compliance. However, when these capsules contain high oil content, they present significant challenges…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with testing capsules containing high API load.

April 13, 2025 Admin

Problems with testing capsules containing high API load. Problems with testing capsules containing high API load. Introduction: In the pharmaceutical industry, capsules are a popular solid oral dosage form due to their versatility and ease of administration. As the demand for high-dose medications increases, the challenge of creating capsules with a high Active Pharmaceutical Ingredient…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate validation of capsule disintegration profiles for multi-particulate capsules.

April 13, 2025 Admin

Inadequate validation of capsule disintegration profiles for multi-particulate capsules. Inadequate validation of capsule disintegration profiles for multi-particulate capsules. Introduction: In the pharmaceutical industry, the validation of capsule disintegration profiles is a critical aspect of ensuring drug efficacy and patient safety. This is particularly important for multi-particulate capsules, which can offer benefits such as improved bioavailability…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring compliance with bioequivalence requirements for capsules.

April 9, 2025 Admin

Difficulty in ensuring compliance with bioequivalence requirements for capsules. Difficulty in ensuring compliance with bioequivalence requirements for capsules. Introduction: In the pharmaceutical industry, ensuring that generic formulations are bioequivalent to their branded counterparts is crucial. Bioequivalence ensures that a generic drug releases its active ingredient into the bloodstream at the same rate and level as…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms