Tag: [API degradation

Managing API Degradation in Sugar-Coated Tablets During Stability Studies

June 4, 2025 Admin

Managing API Degradation in Sugar-Coated Tablets During Stability Studies Managing API Degradation in Sugar-Coated Tablets During Stability Studies Introduction: In the pharmaceutical industry, ensuring the stability and efficacy of a drug product throughout its shelf life is of paramount importance. Sugar-coated tablets, a popular dosage form due to their aesthetic appeal and ease of ingestion,…

Solid Dosage form, Tablets

Managing API Migration in Multi-API Tablets During Stability Testing

May 11, 2025 Admin

Managing API Migration in Multi-API Tablets During Stability Testing Managing API Migration in Multi-API Tablets During Stability Testing Introduction: In the ever-evolving world of pharmaceuticals, the development of multi-active pharmaceutical ingredient (API) tablets has gained significant momentum. These formulations offer the advantage of delivering multiple therapeutic effects in a single dose, enhancing patient compliance and…

Solid Dosage form, Tablets

Troubleshooting API Loss in Extended Release Tablets Stored at High Humidity

May 6, 2025 Admin

Troubleshooting API Loss in Extended Release Tablets Stored at High Humidity Troubleshooting API Loss in Extended Release Tablets Stored at High Humidity Introduction: Extended release tablets are a cornerstone of modern pharmaceutical formulations, offering controlled release of active pharmaceutical ingredients (APIs) over time to improve patient compliance and therapeutic efficacy. However, when these tablets are…

Solid Dosage form, Tablets

Managing API Degradation in Film-Coated Tablets Stored at High Temperatures

May 1, 2025 Admin

Managing API Degradation in Film-Coated Tablets Stored at High Temperatures Managing API Degradation in Film-Coated Tablets Stored at High Temperatures Introduction: In the pharmaceutical industry, the stability of Active Pharmaceutical Ingredients (APIs) is crucial for ensuring the efficacy and safety of medications. Film-coated tablets are a popular dosage form, offering benefits such as ease of…

Solid Dosage form, Tablets

Challenges in assessing the stability of capsules containing biological APIs.

April 27, 2025 Admin

Challenges in assessing the stability of capsules containing biological APIs. Challenges in assessing the stability of capsules containing biological APIs. Introduction: The pharmaceutical industry is increasingly focusing on the development of capsules containing biological Active Pharmaceutical Ingredients (APIs) due to their potential in treating various complex diseases. However, ensuring the stability of these capsules poses…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in assessing the stability of capsules containing low-dose APIs.

April 21, 2025 Admin

Difficulty in assessing the stability of capsules containing low-dose APIs. Difficulty in assessing the stability of capsules containing low-dose APIs. Introduction: In the pharmaceutical industry, ensuring the stability of drug products is paramount, particularly when dealing with capsules containing low-dose Active Pharmaceutical Ingredients (APIs). Stability refers to the ability of a drug product to maintain…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Ensuring API Stability in Freeze-Thaw Cycles for Temperature-Sensitive Tablets

April 19, 2025 Admin

Ensuring API Stability in Freeze-Thaw Cycles for Temperature-Sensitive Tablets Ensuring API Stability in Freeze-Thaw Cycles for Temperature-Sensitive Tablets Introduction: Active Pharmaceutical Ingredients (APIs) are the heart of any medication, providing the therapeutic effect intended for the patient. In the realm of solid dosage forms, particularly tablets, preserving the stability of APIs is crucial. Temperature-sensitive tablets,…

Solid Dosage form, Tablets

Poor reproducibility in API stability data for high-dose capsules.

April 15, 2025 Admin

Poor reproducibility in API stability data for high-dose capsules. Poor reproducibility in API stability data for high-dose capsules Introduction: In the pharmaceutical industry, the stability of active pharmaceutical ingredients (APIs) is crucial for ensuring drug safety and efficacy. For high-dose capsules, achieving consistent and reproducible stability data is particularly challenging. Variability in stability data can…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with predicting the stability of capsules containing sensitive APIs.

April 6, 2025 Admin

Problems with predicting the stability of capsules containing sensitive APIs. Problems with Predicting the Stability of Capsules Containing Sensitive APIs Introduction: In the pharmaceutical industry, ensuring the stability of drug products is paramount to maintaining efficacy and safety throughout their shelf life. Capsules, both hard and soft gelatin, are popular dosage forms due to their…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule drying processes for thermosensitive APIs.

April 1, 2025 Admin

Difficulty in validating capsule drying processes for thermosensitive APIs. Difficulty in validating capsule drying processes for thermosensitive APIs Introduction: In the realm of pharmaceutical manufacturing, ensuring the stability and efficacy of Active Pharmaceutical Ingredients (APIs) is paramount. Thermosensitive APIs, which are prone to degradation at elevated temperatures, pose unique challenges. As capsules, especially hard and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Ensuring Robustness of API Potency in Sustained Release Tablets Over Time

March 14, 2025 Admin

Ensuring Robustness of API Potency in Sustained Release Tablets Over Time Ensuring Robustness of API Potency in Sustained Release Tablets Over Time Introduction: The development of sustained release tablets represents a significant advancement in pharmaceutical technology, aiming to provide consistent therapeutic effects over extended periods. These formulations are essential for enhancing patient compliance, minimizing dosing…

Solid Dosage form, Tablets