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Comparison of Disintegration Test and Dissolution Test Aspect Disintegration Test Dissolution Test Purpose To assess how quickly a tablet breaks apart into small particles when exposed to a fluid environment, simulating the conditions in the human body. To determine the rate at which the drug is released from the tablet and becomes available for absorption…
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Dissolution Test in Tablet Formulation The dissolution test is a critical quality control test conducted during tablet formulation to assess the rate at which a tablet’s active pharmaceutical ingredient (API) dissolves and becomes available for absorption in a specified fluid environment. This test provides valuable information about the drug’s release characteristics from the tablet and…
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Disintegration Test in Tablet Formulation The disintegration test is a crucial quality control test conducted during tablet formulation to assess how quickly a tablet disintegrates into small particles when exposed to a specified fluid environment. The disintegration time is an essential parameter that influences drug release and absorption rates. This test ensures that the tablet…
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Determination of Tablet Hardness Tablet hardness, also known as tablet crushing strength, is a critical quality attribute that determines the tablet’s ability to withstand mechanical stress during handling, packaging, and transportation. The hardness of a tablet directly influences its disintegration and dissolution properties, as well as patient compliance. Various methods are used to determine tablet…
Advantages of Dry Granulation Over Wet Granulation Advantages Dry Granulation Wet Granulation Drug Stability Dry granulation is suitable for moisture-sensitive drugs as it avoids exposure to water or solvents, preserving drug stability. Wet granulation may cause degradation of moisture-sensitive drugs due to exposure to water or solvents. Process Efficiency Dry granulation requires fewer equipment and…
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Dry Granulation in Tablet Manufacturing Dry granulation, also known as pre-compression or slugging, is a tablet manufacturing process that involves compacting the powder blend without using any liquid binder. This method is suitable for drugs that are sensitive to moisture or heat and cannot undergo wet granulation. Dry granulation is particularly advantageous when dealing with…
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Wet Granulation in Tablet Manufacturing Wet granulation is a widely used process in tablet manufacturing that involves the agglomeration of powder particles to form granules. This process is essential for improving the flow properties, compressibility, and uniformity of the drug formulation, ultimately leading to the production of high-quality tablets. Here’s a step-by-step explanation of the…
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Immediate-Release Tablets Immediate-release tablets are a common type of pharmaceutical dosage form designed to release the active drug ingredient quickly after ingestion. These tablets are formulated to disintegrate rapidly in the gastrointestinal tract, allowing the drug to be absorbed into the bloodstream at a faster rate compared to other oral dosage forms. Characteristics of Immediate-Release…
Classification of Tablets based on Size and Shape Tablets can be classified into various categories based on their size and shape, which are determined by the tablet’s intended use, patient compliance, and manufacturing considerations. The classification of tablets based on size and shape is as follows: 1. Round Tablets Round tablets are one of the…
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Role of Excipients in Tablet Manufacturing Excipients play a crucial role in tablet manufacturing, serving various purposes to ensure the quality, stability, and effectiveness of the final tablet product. The role of excipients can be summarized as follows: 1. Binder: Binders help hold the tablet’s ingredients together, ensuring the uniform distribution of the active pharmaceutical…
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Tablets can be classified into various types based on their formulation, which determines their drug release characteristics and intended use. The main types of tablets are as follows: 1. Immediate-Release Tablets Immediate-release tablets are designed to release the entire dose of the drug rapidly upon ingestion. These tablets disintegrate and dissolve quickly in the gastrointestinal…
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Pharmaceutical Manufacturing – Tablets vs. Capsules Tablets and capsules are two common oral dosage forms used in pharmaceutical manufacturing, and they have distinct characteristics that set them apart. Here are the main differences between tablets and capsules: Tablets Form: Tablets are solid dosage forms prepared by compressing a mixture of active pharmaceutical ingredients (APIs) and…