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Powder sticking to punches, commonly known as “sticking,” is a frequent issue in tablet manufacturing. It occurs when powder adheres to the punch faces instead of compacting properly within the die cavity. This problem can lead to defective tablets, production delays, and increased machine wear.
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Powder flowability is a critical factor in tablet manufacturing. It determines how well powder particles flow into the die cavity during the compression process, directly impacting tablet uniformity, weight, and quality. Poor flowability can lead to weight variation, capping, lamination, and other production defects.
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Tablet lamination is a defect in pharmaceutical tablet production where the tablet separates into layers after compression. This can occur during production, packaging, or even storage. Lamination compromises the tablet’s integrity, appearance, and functionality, making it a serious issue for pharmaceutical manufacturers.
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Tablet compression force plays a critical role in ensuring the uniformity, strength, and efficacy of tablets. During manufacturing, the applied force determines how tightly the powder particles bond, directly impacting the tablet’s hardness, friability, and disintegration time. Incorrect compression force can result in defects such as weight variation, capping, or lamination.
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Tablet capping refers to a manufacturing defect where the top or bottom layer of a tablet separates or breaks off during or after compression. This issue compromises the integrity, efficacy, and appearance of the tablet, leading to potential product rejection and financial loss.
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Weight variation in tablet manufacturing occurs when tablets from the same batch exhibit inconsistent weights. This problem not only affects product quality but also impacts the therapeutic efficacy of the medication. It can lead to regulatory non-compliance and financial losses due to rejections or recalls.
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Advantages of Using Pre-formulated Direct Compression Excipients Pre-formulated direct compression excipients are ready-to-use blends of various excipients specifically designed for direct compression tablet manufacturing. These pre-formulated excipients offer several advantages over traditional individual excipients. Here are the key advantages of using pre-formulated direct compression excipients: 1. Simplified Formulation Development Pre-formulated excipients streamline the tablet formulation…
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Manufacturing Process of Multi-Layer Tablets Multi-layer tablets are pharmaceutical tablets that consist of two or more distinct layers of different drug formulations. These layers may release the active pharmaceutical ingredients (APIs) at different rates or provide other specific functionalities, such as immediate release followed by sustained release. The manufacturing process of multi-layer tablets involves careful…
Different Tablet Scoring Techniques Tablet scoring is a process used to create a groove or shallow indentation on a tablet’s surface. The scoring facilitates breaking the tablet into smaller parts, allowing patients to adjust the dose as needed. Tablet scoring is particularly useful for patients who have difficulty swallowing or need a lower dosage strength…
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Formulation of Sustained-Release Tablets Sustained-release tablets, also known as extended-release tablets or controlled-release tablets, are designed to release the active pharmaceutical ingredient (API) over an extended period, maintaining a steady and controlled drug release profile. The formulation of sustained-release tablets requires careful selection of excipients and incorporation of drug release mechanisms to achieve the desired…
Purpose of Using Glidants in Tablet Manufacturing Glidants, also known as lubricating glidants or flow aids, are additives used in tablet manufacturing to improve the flow properties of the tablet blend. They serve the crucial purpose of enhancing the flowability of powders or granules, making the tablet manufacturing process more efficient and consistent. Glidants play…
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Importance of Using Appropriate Lubricants in Tablet Compression Lubricants play a crucial role in tablet compression, as they help facilitate the tablet manufacturing process and ensure the production of high-quality tablets. Lubricants are added to tablet formulations to reduce friction between the tablet granules and the surfaces of the tablet punches and dies during compression….
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