Tips for Tablets

Excipients are inactive ingredients in pharmaceutical formulations that play essential roles in tablet manufacturing, stability, and drug release. In slow-release tablets, the choice of excipients directly impacts the controlled-release profile, stability, and therapeutic efficacy. Selecting the right excipients ensures the desired drug release rate while maintaining the tablet’s mechanical strength and stability.
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Lubricants are essential excipients used in tablet formulations to reduce friction between the tablet and the die wall during compression and ejection. However, excessive use of lubricants, such as magnesium stearate, can negatively impact tablet quality. Problems include delayed dissolution, reduced tablet hardness, poor binding, and altered API release profiles.
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Direct compression is a widely used technique in tablet manufacturing, where powdered materials are compressed directly into tablets without the need for granulation. This method is particularly popular for formulations like Immediate-Release Tablets, Orally Disintegrating Tablets (ODTs), and Film-Coated Tablets. Its simplicity, cost-effectiveness, and suitability for heat- and moisture-sensitive drugs make it a preferred choice in pharmaceutical manufacturing. However, like any method, it comes with its set of advantages and challenges.
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Tablet compression is a critical step in pharmaceutical manufacturing where powder mixtures are compacted into solid doses using a tablet press. This process ensures that tablets like Immediate-Release Tablets, Orally Disintegrating Tablets (ODTs), and Film-Coated Tablets meet desired quality standards in terms of size, shape, and hardness. For complex formulations such as Compression-Coated Tablets, precise compression is even more essential to maintain functionality.
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Dry Granulation has been a cornerstone of pharmaceutical tablet production for decades. As a moisture- and heat-free process, it provides a reliable method for creating tablets like Immediate-Release Tablets and Compression-Coated Tablets. Recent advancements in this technology are revolutionizing how tablets are manufactured, enabling greater precision and efficiency in producing complex formulations such as Layered Tablets and Film-Coated Tablets.
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In pharmaceutical manufacturing, capping occurs when the top or bottom layer of a tablet separates partially or completely from the main body during tablet compression. This defect compromises the tablet’s integrity, appearance, and functionality, especially for specialized formulations like Immediate-Release Tablets and Compression-Coated Tablets.
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In the pharmaceutical industry, lubricants play a critical role in ensuring smooth tablet manufacturing. They minimize friction during the compression and ejection processes, preventing damage to both the Immediate-Release Tablets and the machinery involved. Proper selection and use of Lubricant in Tablet Manufacturing directly influence tablet quality, weight uniformity, and Tablet Hardness Testing.
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Dry Granulation is one of the most critical processes in tablet production, especially when the active pharmaceutical ingredients (APIs) are sensitive to moisture or heat. Unlike wet granulation, this method eliminates the need for liquid binders, making it ideal for creating Immediate-Release Tablets, Compression-Coated Tablets, and Tablets for Suspension.
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In modern pharmaceutical manufacturing, tablet coating plays a vital role in ensuring the stability, functionality, and patient compliance of medications. Coatings not only improve the tablet’s appearance but also aid in targeted drug delivery, taste masking, and protection from environmental factors. The various coating types, including Film-Coated Tablets, Sugar-Coated Tablets, Enteric-Coated Tablets, and Layered Tablets, cater to different therapeutic and manufacturing needs.
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Rapid dissolution tablets are designed to disintegrate and release their active pharmaceutical ingredients (APIs) quickly in the gastrointestinal tract, ensuring swift therapeutic action. These tablets are commonly used for pain relief, fever reduction, or other conditions where immediate effect is necessary. Achieving rapid dissolution requires careful formulation and manufacturing processes to ensure efficacy and patient satisfaction.
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Binder concentration issues refer to problems arising from improper amounts of binding agents used during the granulation process. Binders play a critical role in enhancing granule strength, flowability, and compressibility. However, incorrect binder levels can lead to problems such as poor granule cohesion, excessive hardness, or tablet disintegration failures.
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Uniform API distribution in tablet formulations ensures that each dosage contains the correct amount of active pharmaceutical ingredient (API). Inconsistent distribution can lead to dosage variability, reduced therapeutic efficacy, and regulatory non-compliance. Achieving uniformity is particularly challenging when APIs have poor flow properties, low concentrations, or large particle size differences compared to excipients.
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