Tips for Tablets

Controlling moisture content is a critical factor in pharmaceutical manufacturing, as it directly impacts tablet stability. Excess moisture can compromise the physical integrity, disintegration, and dissolution properties of tablets, particularly for sensitive formulations like Immediate-Release Tablets, Film-Coated Tablets, and Orally Disintegrating Tablets (ODTs). On the other hand, insufficient moisture may lead to brittle tablets that crumble during handling or packaging.
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In pharmaceutical manufacturing, the shape of a tablet plays a crucial role in patient compliance, ease of use, and overall effectiveness. Whether designing Immediate-Release Tablets, Orally Disintegrating Tablets (ODTs), or specialized formulations like Film-Coated Tablets and Sugar-Coated Tablets, selecting the right tablet shape can greatly influence a patient’s experience and adherence to their medication regimen.
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Tablet coating is a vital step in pharmaceutical manufacturing, serving multiple purposes such as protecting the active ingredients, enhancing aesthetics, masking unpleasant tastes, and controlling drug release. Coated tablets like Film-Coated Tablets, Sugar-Coated Tablets, and Enteric-Coated Tablets are tailored for specific therapeutic and patient needs. Advanced methods like Compression-Coated Tablets further expand the functionality of coatings in drug delivery systems.
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Tablet hardness is a critical parameter in tablet manufacturing, as it directly impacts the durability, disintegration, and dissolution properties of tablets. Whether producing Immediate-Release Tablets, Film-Coated Tablets, or Orally Disintegrating Tablets (ODTs), maintaining optimal hardness ensures tablets meet therapeutic and quality standards.
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In the pharmaceutical industry, quality control ensures that tablets meet predefined standards for safety, efficacy, and consistency. Whether producing Immediate-Release Tablets, Orally Disintegrating Tablets (ODTs), or advanced formulations like Compression-Coated Tablets and Film-Coated Tablets, robust quality control systems are vital. This step-by-step guide outlines the key processes involved in maintaining high standards throughout tablet manufacturing.
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Tablet coating is a crucial process in pharmaceutical manufacturing that enhances tablet performance, appearance, and functionality. Coating not only improves the stability and taste of the tablet but also supports targeted drug delivery. From Film-Coated Tablets to advanced Compression-Coated Tablets and Enteric-Coated Tablets, each coating type serves a specific purpose in modern drug formulation.
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Tablet damage during blister packaging is a common issue that can lead to chipped edges, broken tablets, or loss of coating integrity. Such damage not only affects the product’s appearance but also its efficacy and stability. Packaging-related tablet damage often occurs due to mechanical stress, improper equipment settings, or inadequate material selection.
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Low-dose tablets, where the active pharmaceutical ingredient (API) is present in minute quantities, pose unique challenges during granule compression. Maintaining uniformity, achieving proper compaction, and preventing segregation of APIs and excipients are critical to ensure consistent quality and efficacy. Granule compression issues in low-dose formulations can result in weight variation, inadequate hardness, or compromised drug release.
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Controlled-release coated tablets are designed to deliver the active pharmaceutical ingredient (API) at a predetermined rate, duration, and location within the gastrointestinal tract. The coating plays a vital role in regulating drug release, providing therapeutic efficacy over an extended period while minimizing side effects and dosing frequency.
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Poorly soluble drugs present significant challenges in pharmaceutical formulation due to their limited ability to dissolve in the gastrointestinal tract. For immediate-release tablets, rapid dissolution and absorption are critical to achieve the desired therapeutic effect. Enhancing the solubility and dissolution rate of such drugs is essential for effective formulation and patient outcomes.
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Powder flowability is a critical factor in tablet manufacturing as it ensures uniform die filling, consistent tablet weight, and efficient compression. Poor flow properties can lead to issues such as weight variation, segregation, and inconsistent API distribution. Enhancing powder flowability improves manufacturing efficiency and ensures high-quality tablets.
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Tablet layer separation, also known as delamination, occurs when the individual layers of a multilayer tablet fail to adhere to each other. This structural defect can lead to compromised drug efficacy, inconsistent release profiles, and regulatory non-compliance. Layer separation is often caused by factors such as poor adhesion, compression force imbalances, or incompatible formulation components.
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