Tips for Tablets

Disintegration aids are crucial in the formulation of sugar-coated tablets, as they facilitate the rapid breakdown of the tablet in the gastrointestinal tract. The sugar coating serves to protect the API, mask the taste, and provide aesthetic appeal, but it also affects the tablet’s disintegration properties. A well-designed sugar-coated tablet should disintegrate efficiently after ingestion to release the API at the appropriate rate. This article provides essential tips and tricks for selecting effective disintegration aids for sugar-coated tablets, ensuring that the final product meets the desired performance standards for rapid dissolution and bioavailability.
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Controlled agglomeration is a crucial step in the granulation process, which plays an integral role in the production of tablets and other solid dosage forms. The technique involves the controlled formation of granules by binding fine particles together, improving flowability, compressibility, and uniformity in the final product. When done correctly, controlled agglomeration can enhance the quality of granules, optimize the tablet manufacturing process, and improve the overall quality of the final product. This expert guide delves into the role of controlled agglomeration in granulation, highlighting its importance and offering best practices for implementing it in the pharmaceutical manufacturing process.
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Coating is a critical step in the tablet manufacturing process, especially for film-coated tablets, which require precise control over coating thickness, uniformity, and quality. However, coating can be a time-consuming process, and reducing coating time without compromising the final product’s integrity is a key area of research and innovation in the pharmaceutical industry. Film coatings serve to protect the active pharmaceutical ingredient (API), enhance tablet appearance, and control the drug release profile. This article discusses the latest strategies and research trends that focus on reducing coating time while maintaining the desired coating quality, which ultimately contributes to improving manufacturing efficiency and lowering production costs.
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Tablet erosion is a common issue in controlled release (CR) tablet formulations, where the tablet erodes too quickly or inconsistently during the release process. This can lead to a burst release of the active pharmaceutical ingredient (API), causing fluctuations in drug concentration and reducing therapeutic efficacy. In controlled release formulations, it’s critical to maintain a steady and predictable release of the API over an extended period. This troubleshooting guide provides step-by-step solutions to address tablet erosion issues in controlled release formulations and optimize drug release profiles.
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Incorporating nutraceuticals into pharmaceutical formulations, particularly in immediate release (IR) tablets, presents several challenges. Nutraceuticals, which include dietary supplements, vitamins, minerals, and herbal extracts, often have different physicochemical properties than conventional APIs. These differences can make formulation difficult, especially in terms of solubility, stability, and bioavailability. Immediate release tablets are designed to rapidly dissolve and release the active ingredient upon ingestion, which requires careful consideration of the excipient selection, tablet design, and manufacturing process. This case study explores the challenges faced by a pharmaceutical company when attempting to incorporate a popular nutraceutical—curcumin—into an IR tablet formulation and the solutions they employed to overcome these issues.
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Excipient-drug interactions are a crucial consideration in the development of extended release (ER) tablets. The selection of excipients, including binders, fillers, disintegrants, and polymers, can significantly affect the release profile of the active pharmaceutical ingredient (API). Inadequate excipient-drug compatibility may lead to unexpected interactions that impact the stability, bioavailability, and performance of the tablet. Conducting excipient-drug interaction studies is essential to identify potential incompatibilities early in the formulation process. This step-by-step guide outlines how to carry out excipient-drug interaction studies to optimize the development of extended release tablets.
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