Tips for Tablets

Granule segregation refers to the separation of particles or granules based on size, density, or composition during processing steps such as drying and milling. Segregation can result in inconsistent granule properties, poor flowability, uneven drug distribution, and variability in tablet compression. Addressing granule segregation is crucial for maintaining the quality and uniformity of pharmaceutical products.
Click to read the full article.

Over-agglomeration refers to the excessive clumping of particles during the granulation process in a fluidized bed granulator. This issue can lead to oversized granules, poor flow properties, uneven drug distribution, and challenges during tablet compression. Over-agglomeration is caused by factors such as excessive binder addition, inadequate process parameters, or improper equipment settings.
Click to read the full article.

Poor binder distribution occurs when the binder, used to ensure granule cohesiveness, is unevenly dispersed throughout the granulated material. This can lead to problems such as inconsistent granule size, weak granules, or excessive fines, ultimately impacting tablet quality, compression, and drug release. Identifying and addressing binder distribution issues is critical to ensure a robust wet granulation process.
Click to read the full article.

Roller compaction is a dry granulation process used to produce granules by compacting powder blends between two rollers. The resulting compacted ribbons are milled to form granules of the desired size. Optimizing roller compaction parameters is critical to achieving uniform granules, which are essential for consistent tablet compression, drug release profiles, and overall product quality.
Click to read the full article.

Adhesion issues occur when layers of coating in multi-layer tablets fail to bond properly. This can result in peeling, cracking, or delamination, compromising the tablet’s appearance, functionality, and drug release profile. Adhesion problems can stem from improper formulation, environmental factors, or equipment settings during the coating process.
Click to read the full article.

Color mottling refers to uneven or patchy color distribution on the surface of film-coated tablets. This defect can negatively impact the aesthetic appeal and perceived quality of pharmaceutical products. Color mottling is often caused by formulation inconsistencies, inadequate process parameters, or environmental factors during the coating process.
Click to read the full article.