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Role of Binders in Tablet Formulation Binders are essential excipients used in tablet formulation to impart cohesiveness to the powders in the tablet blend. They play a crucial role in ensuring that the tablet maintains its shape and integrity during and after compression. Binders are necessary because many active pharmaceutical ingredients (APIs) and other excipients…
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Process of Dry Powder Filling in Capsule Production Dry powder filling is a common method used in capsule production to fill capsules with powdered or granulated materials, including active pharmaceutical ingredients (APIs) and excipients. The process involves several steps to ensure accurate and uniform filling of the capsules. Here’s a detailed explanation of the dry…
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Production of Effervescent Tablets and Their Advantages Production of Effervescent Tablets Effervescent tablets are a unique dosage form that rapidly dissolves in water, producing a pleasant effervescence (fizzing) due to the release of carbon dioxide. The production of effervescent tablets involves specific formulation and manufacturing techniques. Here’s an overview of the production process: Formulation The…
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Optimizing Capsule Formulations for Better Bioavailability Achieving better bioavailability in capsule formulations is a critical goal in pharmaceutical development. Bioavailability refers to the extent and rate at which the active pharmaceutical ingredient (API) in a capsule is absorbed into the bloodstream and becomes available for therapeutic action. Several strategies can be employed to optimize capsule…
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Challenges in Manufacturing Sublingual Tablets Sublingual tablets are a specialized type of oral dosage form that is designed to be placed under the tongue, where the drug is rapidly absorbed into the bloodstream through the sublingual mucosa. While sublingual tablets offer several advantages, such as faster onset of action and avoidance of first-pass metabolism, their…
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Preparation of Enteric-Coated Capsules Enteric-coated capsules are designed to resist disintegration and dissolution in the acidic environment of the stomach. Instead, they disintegrate and release their contents in the more alkaline environment of the small intestine. The enteric coating helps protect sensitive drugs from degradation in the stomach and allows for targeted drug release. Here’s…
Ensuring Content Uniformity in Tablet Production Content uniformity is a critical quality parameter in tablet production, ensuring that each tablet within a batch contains the correct and uniform amount of active pharmaceutical ingredient (API). Deviations in content uniformity can lead to dosing inaccuracies and affect the safety and efficacy of the medication. Here are the…
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Tablet Friability: Determination and Importance Tablet Friability Determination Tablet friability is a critical quality attribute assessed during tablet manufacturing to evaluate the tablet’s mechanical strength and resistance to abrasion or damage during handling and packaging. The test to determine tablet friability involves subjecting a sample of tablets to mechanical stress by rotating them in a…
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Steps Involved in Tablet Compression Tablet compression is a crucial step in the manufacturing process of solid oral dosage forms. It involves transforming a blend of active pharmaceutical ingredient (API) and excipients into a compact tablet form using a tablet press. Here are the key steps involved in tablet compression: 1. Pre-Compression Stage Material Preparation:…
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Filling Process for Soft Gelatin Capsules Soft gelatin capsules (SGC) are popular dosage forms used to deliver liquid or semi-solid formulations. The filling process for soft gelatin capsules involves several steps to ensure accurate dosing and uniformity in each capsule. Below, is a typical process of filling soft gelatin capsules: 1. Gelatin Shell Preparation The…
Types of Capsule Shells Used in Manufacturing Capsules are popular pharmaceutical dosage forms used to encapsulate and deliver medications. There are two main types of capsule shells used in manufacturing, each with its unique properties and applications. 1. Hard Gelatin Capsules Hard gelatin capsules (HGC) are the most commonly used type of capsules in the…
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Standardization and Classification of Capsule Sizes Capsules come in various sizes, each designed to hold different quantities of active pharmaceutical ingredients (APIs) and excipients. Standardization and classification of capsule sizes ensure uniformity in the pharmaceutical industry, making it easier for manufacturers and healthcare professionals to prescribe and dispense medications. Standardization of Capsule Sizes Capsule sizes…
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