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Preventing Oxidation of Active Ingredients in Aerosols

Posted on January 11, 2025 By Admin

Preventing Oxidation of Active Ingredients in Aerosols

Step-by-Step Guide to Protecting Aerosol Ingredients from Oxidation

Why Is Oxidation a Concern in Aerosol Manufacturing?

Oxidation occurs when active ingredients in aerosol formulations react with oxygen, leading to degradation, color changes, and reduced efficacy. Preventing oxidation is essential to maintaining product quality and stability.

Steps to Prevent Oxidation

Step 1: Use Antioxidants

Add antioxidants to the formulation to neutralize reactive oxygen species and protect active ingredients from degradation.

Step 2: Select Appropriate Packaging

Choose aerosol packaging solutions with airtight seals and materials that minimize oxygen permeability.

Step 3: Replace Air with Inert Gas

Flush the canister with inert gases like nitrogen or

argon to displace oxygen before sealing.

Pharma Tip:  Dealing with Aerosol Performance Variability Over Time

Step 4: Store Under Controlled Conditions

Maintain low temperatures and avoid exposure to light, as these factors can accelerate oxidation.

Testing for Oxidation

Conduct regular stability testing, including visual inspections and chemical analyses, to monitor oxidation levels and ensure product integrity.

Conclusion

Preventing oxidation in aerosol manufacturing involves using antioxidants, selecting proper packaging, and maintaining optimal storage conditions. These steps help preserve product quality and extend shelf life.

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