Pharma.Tips – Page 84 – Unlocking Pharma's Secrets: Your Ultimate Guide to Pharmaceutical Success!

Investigating Failures in Dissolution Testing for Sustained Release Tablets

March 22, 2025 Admin

Investigating Failures in Dissolution Testing for Sustained Release Tablets Investigating Failures in Dissolution Testing for Sustained Release Tablets Introduction: The pharmaceutical industry is a cornerstone of modern medicine, with sustained release tablets playing a crucial role in controlled drug delivery systems. These formulations are designed to release the active pharmaceutical ingredient (API) at a predetermined…

Solid Dosage form, Tablets

Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing

March 22, 2025 Admin

Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing Introduction: In the pharmaceutical industry, enteric-coated tablets play a crucial role in ensuring that active pharmaceutical ingredients (APIs) are delivered to the intestine, bypassing the acidic environment of the stomach. This not only protects the drug from…

Solid Dosage form, Tablets

Inadequate validation of capsule performance under variable storage conditions.

March 22, 2025 Admin

Inadequate validation of capsule performance under variable storage conditions. Inadequate validation of capsule performance under variable storage conditions Introduction: In the pharmaceutical industry, ensuring the stability and performance of dosage forms, such as capsules, under varying storage conditions is crucial. Capsules, whether hard or soft gelatin, are popular for their ease of administration and ability…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Ensuring Adequacy of Water Flow Rates in Purified Water Systems

March 22, 2025 Admin

Ensuring Adequacy of Water Flow Rates in Purified Water Systems Ensuring Adequacy of Water Flow Rates in Purified Water Systems Introduction: In the pharmaceutical industry, purified water is a critical component used in various manufacturing processes, including the production of solid dosage forms such as tablets. Ensuring the adequacy of water flow rates in purified…

Solid Dosage form, Tablets

Managing Root Cause Analysis for Failures in Stability Studies

March 22, 2025 Admin

Managing Root Cause Analysis for Failures in Stability Studies Managing Root Cause Analysis for Failures in Stability Studies Introduction: In the pharmaceutical industry, stability studies are crucial to ensuring that a drug product maintains its intended quality, safety, and efficacy throughout its shelf life. Failures in stability studies can lead to significant setbacks in drug…

Solid Dosage form, Tablets

Optimization of Coating Process Parameters for Sugar-Coated Tablets

March 22, 2025 Admin

Optimization of Coating Process Parameters for Sugar-Coated Tablets Expert Guide to Optimizing Coating Process Parameters for Sugar-Coated Tablets Overview: Sugar coating is a traditional method used in pharmaceutical manufacturing to enhance tablet appearance, mask taste, and provide a protective layer. However, achieving a uniform and defect-free sugar coating requires careful optimization of process parameters. Issues…

Tablets

Managing Calibration Failures in Moisture Sensors for Fluid Bed Dryers

March 22, 2025 Admin

Managing Calibration Failures in Moisture Sensors for Fluid Bed Dryers Managing Calibration Failures in Moisture Sensors for Fluid Bed Dryers Introduction: In pharmaceutical manufacturing, fluid bed dryers play a crucial role in ensuring the precise moisture content of solid dosage forms, such as tablets. The accuracy of moisture sensors in these dryers is vital for…

Solid Dosage form, Tablets

How to Formulate Floating Tablets for Gastric Retention

March 22, 2025 Admin

How to Formulate Floating Tablets for Gastric Retention Step-by-Step Guide to Formulating Floating Tablets for Gastric Retention What Are Floating Tablets? Floating tablets are a type of gastro-retentive drug delivery system (GRDDS) designed to remain buoyant in the stomach for extended periods, ensuring prolonged drug release and improved bioavailability. These tablets are particularly useful for…

Tablets

Managing Layer Overlap in Multi-Layer Tablets During Compression

March 22, 2025 Admin

Managing Layer Overlap in Multi-Layer Tablets During Compression Managing Layer Overlap in Multi-Layer Tablets During Compression Introduction: Multi-layer tablets are an advanced pharmaceutical dosage form that allows for the combination of different active pharmaceutical ingredients (APIs) or release profiles in a single unit. This technology creates opportunities for innovative drug delivery solutions, improving patient compliance…

Solid Dosage form, Tablets

Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets

March 22, 2025 Admin

Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets Introduction: In the pharmaceutical industry, film-coated tablets represent a significant portion of solid dosage forms due to their enhanced stability, ease of swallowing, and aesthetic attributes. The coating process is critical, as it affects the tablet’s performance and patient…

Solid Dosage form, Tablets

Poor reproducibility in rinse sampling results during cleaning validation.

March 22, 2025 Admin

Poor reproducibility in rinse sampling results during cleaning validation. Poor reproducibility in rinse sampling results during cleaning validation. Introduction: In the pharmaceutical industry, ensuring that manufacturing equipment is free from contaminants is crucial for maintaining product quality and safety. Cleaning validation is a critical process that verifies the effectiveness of cleaning procedures. One of the…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Non-Adherence of Coating Layers in Extended Release Tablets

March 22, 2025 Admin

Troubleshooting Non-Adherence of Coating Layers in Extended Release Tablets Troubleshooting Non-Adherence of Coating Layers in Extended Release Tablets Introduction: In the pharmaceutical industry, extended release tablets play a crucial role in delivering medication over a prolonged period, enhancing patient compliance and therapeutic efficacy. However, one of the persistent challenges in their production is the non-adherence…

Solid Dosage form, Tablets