Tips for Drug Discovery

Emulsion formulations are widely used in drug delivery systems, particularly for poorly water-soluble drugs. By using emulsions, drug molecules can be solubilized and delivered in a stable form, improving bioavailability. This FAQ guide explains how to conduct emulsion formulation screening:
Click to read the full article.

Nanoparticles have become a promising strategy for improving the solubility and bioavailability of poorly soluble drugs. By reducing the size of drug particles to the nanoscale, nanoparticles enhance the dissolution rate and facilitate drug absorption. This guide outlines the process of screening drug nanoparticles for solubility enhancement:
Click to read the full article.

Lipid-based formulations are increasingly being used to enhance the solubility and bioavailability of poorly water-soluble drugs. These formulations, which include lipid emulsions, liposomes, and self-emulsifying drug delivery systems (SEDDS), can improve the dissolution of drugs and facilitate their absorption. This guide outlines the steps involved in developing lipid-based formulations for screening:
Click to read the full article.

Polymorphism refers to the ability of a drug’s active pharmaceutical ingredient (API) to exist in more than one crystalline form, each with different physicochemical properties. Screening polymorphs is an essential part of drug development, as the polymorphic form of an API can significantly impact its solubility, stability, and bioavailability. This guide outlines the steps for screening polymorphs of APIs:
Click to read the full article.

Solid dispersion is a technique used to improve the solubility and bioavailability of poorly soluble drugs. By dispersing the active pharmaceutical ingredient (API) in a solid matrix, solid dispersions help overcome solubility limitations and enhance the drug’s dissolution rate. This guide outlines the methods for screening solid dispersions:
Click to read the full article.

High-throughput formulation screening techniques allow for the rapid testing of a large number of drug formulations in a short period. These techniques are particularly useful during the early stages of drug development when researchers need to test multiple formulations for factors such as solubility, stability, and drug release. This guide outlines how to apply high-throughput screening (HTS) in formulation development:
Click to read the full article.

Design of Experiments (DoE) is a powerful statistical methodology used to optimize formulations and processes. In the context of drug development, DoE can help identify the most influential factors affecting drug formulation, such as excipient concentrations, processing parameters, and environmental conditions. This FAQ guide explains how to use DoE in formulation screening:
Click to read the full article.

Compatibility studies between active pharmaceutical ingredients (APIs) and excipients are critical in drug formulation development. The success of a formulation depends on ensuring that the API remains stable and effective when combined with excipients. This guide outlines the steps involved in conducting compatibility studies:
Click to read the full article.

Preformulation studies are crucial in drug development as they help determine the physicochemical properties of a drug candidate, which influence the formulation process. These studies help ensure that the active pharmaceutical ingredient (API) can be effectively delivered to the target site in the body. This guide outlines how to conduct preformulation studies for drug candidates:
Click to read the full article.

Excipients are inactive ingredients that are combined with active pharmaceutical ingredients (APIs) to create drug formulations. Selecting the right excipients is essential to optimize the drug’s stability, solubility, and bioavailability. This article outlines the process for screening excipients for formulation development:
Click to read the full article.

pH-solubility profiling is an important technique for assessing how a drug candidate dissolves in different pH environments. This is particularly important for oral drug formulations, as the drug’s solubility at various pH levels (e.g., in the stomach, small intestine) can affect its absorption and bioavailability. This FAQ guide explains how to conduct pH-solubility profiling of drug candidates:
Click to read the full article.

Stability testing is crucial in the development of screening formulations, as it ensures that the formulations maintain their potency, efficacy, and safety over time. Stability testing evaluates the impact of environmental factors such as temperature, humidity, and light exposure on the formulation’s properties. This guide outlines how to perform stability testing for screening formulations:
Click to read the full article.