Tips for Drug Discovery

Assessing the mechanical properties of drug formulations is crucial for ensuring their integrity, stability, and manufacturability. Mechanical properties such as hardness, friability, and tensile strength play a significant role in determining the physical performance of the formulation, especially for solid dosage forms like tablets and capsules. This guide outlines how to assess the mechanical properties of formulations:
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Prototype formulations are early-stage drug formulations developed for testing and screening purposes. These formulations serve as the foundation for further optimization and refinement before clinical trials. Preparing prototype formulations is a critical step in drug development, as it allows researchers to evaluate the feasibility of the drug’s delivery system. This guide outlines how to prepare prototype formulations for testing:
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Controlled release formulations are designed to release the active pharmaceutical ingredient (API) at a controlled rate, ensuring consistent therapeutic effects over an extended period. The selection of the right polymers is crucial in developing these formulations, as they directly affect the release profile and stability of the drug. This FAQ guide explains how to select polymers for controlled release formulations:
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Moisture sensitivity testing is an essential aspect of formulation development, particularly for drugs that are sensitive to water. Moisture can cause degradation, hydrolysis, or changes in the physical properties of drugs, potentially compromising their efficacy. This guide outlines the steps involved in moisture sensitivity testing:
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Dissolution testing is a critical method used in formulation screening to evaluate how a drug is released from its dosage form (e.g., tablets, capsules). This test helps determine the drug’s solubility and the rate at which it dissolves in a particular solvent, which directly impacts its bioavailability. This guide outlines how to conduct dissolution testing in formulation screening:
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Oral drug delivery is the most commonly used route for administering therapeutic agents. However, improving the absorption and bioavailability of poorly soluble drugs can be challenging. Screening oral delivery systems is crucial for optimizing the formulation to ensure the drug is absorbed effectively. This guide outlines how to conduct oral delivery system screening for formulations:
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Predictive tools in formulation development can help researchers streamline the design process by simulating various formulation parameters and predicting their effects. These tools can reduce the need for extensive trial-and-error experimentation and improve the efficiency of drug development. This FAQ guide explains how to use predictive tools in formulation development:
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Packaging plays a critical role in maintaining the stability and efficacy of drug formulations. Compatibility between the drug product and packaging materials is essential to prevent interactions that could lead to degradation or reduced efficacy. This guide outlines how to test the compatibility of drug formulations with packaging materials:
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Film coating is widely used in tablet formulation to improve stability, control drug release, and enhance the appearance of the tablets. Screening film-coating formulations is essential to ensure the desired properties are achieved, including uniformity, stability, and controlled release. This guide outlines the steps involved in screening film-coating formulations:
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Tablet formulations are one of the most common dosage forms for oral drug delivery. They offer ease of administration, precise dosing, and cost-effectiveness. Developing tablet formulations for screening is crucial for evaluating the drug’s solubility, stability, and bioavailability. This guide outlines the steps involved in developing tablet formulations:
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Injectable formulations are an essential drug delivery system for many therapeutic agents, particularly for drugs that cannot be effectively delivered orally. Screening injectable formulations is crucial for ensuring the stability, solubility, and safety of the drug for parenteral administration. This guide outlines the steps involved in screening injectable formulations:
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Surfactants play a critical role in formulation development, particularly in enhancing the solubility and bioavailability of poorly water-soluble drugs. They act as emulsifiers, solubilizers, or stabilizers, depending on the formulation type. This guide outlines how to select surfactants for drug formulation development:
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