Author: Admin

Dealing with Low Solubility of Actives in Propellant Systems

March 29, 2025 Admin

Dealing with Low Solubility of Actives in Propellant Systems Expert Guide to Addressing Solubility Challenges in Aerosol Propellants Why Is Solubility Important in Aerosol Propellant Systems? The solubility of active ingredients in aerosol propellant systems is critical for ensuring product stability, consistent delivery, and overall efficacy. Poor solubility can lead to phase separation, clogging, and…

Aerosol Formulations

How to Ensure Batch-to-Batch Coating Consistency

March 29, 2025 Admin

How to Ensure Batch-to-Batch Coating Consistency Step-by-Step Guide to Ensuring Batch-to-Batch Coating Consistency Why is Batch-to-Batch Coating Consistency Important? Batch-to-batch coating consistency is critical in pharmaceutical manufacturing to ensure product quality, compliance with regulatory standards, and patient safety. Consistency in coating prevents defects, maintains drug release profiles, and ensures uniform tablet appearance across production batches….

Tablets

Role of Modified Release Excipients in Tablet Formulations

March 29, 2025 Admin

Role of Modified Release Excipients in Tablet Formulations Exploring the Role of Modified Release Excipients in Tablet Formulations Overview: Modified release (MR) excipients play a crucial role in controlling drug release rates, improving bioavailability, and enhancing patient compliance. These excipients enable extended, sustained, or targeted drug delivery, ensuring a consistent therapeutic effect while reducing side…

Tablets

Addressing Poor Adhesion in Film Coatings During Stability Studies

March 29, 2025 Admin

Addressing Poor Adhesion in Film Coatings During Stability Studies Addressing Poor Adhesion in Film Coatings During Stability Studies Introduction: In the realm of pharmaceutical manufacturing, film coatings on tablets are crucial for various reasons, including enhancing tablet stability, controlling drug release, masking unpleasant tastes, and improving aesthetic appeal. However, one of the common challenges faced…

Solid Dosage form, Tablets

Screening Excipients for Formulation Development

March 29, 2025 Admin

Screening Excipients for Formulation Development How to Screen Excipients for Formulation Development Selecting the Right Excipients for Optimal Drug Delivery Excipients are inactive ingredients that are combined with active pharmaceutical ingredients (APIs) to create drug formulations. Selecting the right excipients is essential to optimize the drug’s stability, solubility, and bioavailability. This article outlines the process…

Drug Discovery

Difficulty in assessing stability of capsules containing hygroscopic excipients.

March 28, 2025 Admin

Difficulty in assessing stability of capsules containing hygroscopic excipients. Difficulty in Assessing Stability of Capsules Containing Hygroscopic Excipients Introduction: In the pharmaceutical industry, the stability of drug formulations is paramount to ensuring efficacy and safety. Capsules, both hard and soft gelatin, are popular solid oral dosage forms due to their convenience and patient compliance. However,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Deviations in Batch Records for Multi-Layer Tablets

March 28, 2025 Admin

Addressing Deviations in Batch Records for Multi-Layer Tablets Addressing Deviations in Batch Records for Multi-Layer Tablets Introduction: In the pharmaceutical industry, the production of multi-layer tablets presents unique challenges due to their sophisticated structure and intricate manufacturing process. Multi-layer tablets are designed to deliver multiple active pharmaceutical ingredients (APIs) or to provide controlled release profiles,…

Solid Dosage form, Tablets

Addressing Hydration-Related Issues in Coated Tablet Formulations

March 28, 2025 Admin

Addressing Hydration-Related Issues in Coated Tablet Formulations Step-by-Step Guide to Overcoming Hydration-Related Challenges in Coated Tablet Formulations Overview: Hydration-related issues in coated tablets are a common challenge in pharmaceutical manufacturing, affecting film integrity, drug stability, and release profiles. Moisture from the environment or the coating process itself can lead to film softening, swelling, tackiness, and…

Tablets

Preventing Over-Wetting in Enteric Coating Processes

March 28, 2025 Admin

Preventing Over-Wetting in Enteric Coating Processes Preventing Over-Wetting in Enteric Coating Processes What is Over-Wetting in Enteric Coating Processes? Over-wetting in enteric coating occurs when excessive spray or inadequate drying leads to an overly moist tablet bed. This condition results in defects such as sticking, clumping, peeling, or uneven coating. Preventing over-wetting is critical to…

Tablets

Troubleshooting Uneven Coating Distribution in Film-Coated Tablets

March 28, 2025 Admin

Troubleshooting Uneven Coating Distribution in Film-Coated Tablets Troubleshooting Uneven Coating Distribution in Film-Coated Tablets Introduction: In the pharmaceutical industry, the film coating of tablets is a critical process that enhances the tablet’s aesthetic appeal, provides protection against environmental factors, and can help in controlling the release of the active pharmaceutical ingredient (API). However, achieving a…

Solid Dosage form, Tablets

Managing Failures in Weight Variation Tests for High-Speed Compression Tablets

March 28, 2025 Admin

Managing Failures in Weight Variation Tests for High-Speed Compression Tablets Managing Failures in Weight Variation Tests for High-Speed Compression Tablets Introduction: In the pharmaceutical industry, ensuring the consistency and quality of tablet formulations is paramount. Weight variation tests are critical quality control measures that ensure each tablet contains the intended amount of active pharmaceutical ingredient…

Solid Dosage form, Tablets

Selection of Dispersing Agents in High-Dose API Formulations

March 28, 2025 Admin

Selection of Dispersing Agents in High-Dose API Formulations Latest Advances in Selecting Dispersing Agents for High-Dose API Formulations Overview: Formulating high-dose active pharmaceutical ingredient (API) tablets presents significant challenges due to poor powder flow, compression issues, and inconsistent drug release. One of the key formulation strategies to overcome these issues is the selection of appropriate…

Tablets