Author: Admin

Inadequate validation of high-shear mixers for powder blending.

March 31, 2025 Admin

Inadequate validation of high-shear mixers for powder blending. Inadequate validation of high-shear mixers for powder blending. Introduction: The pharmaceutical industry relies heavily on high-shear mixers for the effective blending of powders, a critical step in the production of solid oral dosage forms such as capsules and tablets. High-shear mixers are valued for their ability to…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Foam Density Problems in Aerosol Products

March 31, 2025 Admin

Troubleshooting Foam Density Problems in Aerosol Products How-to Guide for Resolving Foam Density Issues in Aerosol Formulations What Are Foam Density Problems in Aerosol Products? Foam density refers to the mass per unit volume of foam dispensed from an aerosol product. Inconsistent or incorrect foam density can lead to poor product performance, reduced efficacy, and…

Aerosol Formulations

Addressing Tablet Adhesion in Coating Pans

March 31, 2025 Admin

Addressing Tablet Adhesion in Coating Pans Step-by-Step Guide to Preventing Tablet Adhesion in Coating Pans Overview: Tablet adhesion in coating pans is a common issue that can lead to poor coating uniformity, film defects, and production inefficiencies. This problem arises due to factors such as improper coating formulation, excessive spray rate, inadequate drying, and suboptimal…

Tablets

Troubleshooting Variability in Thickness Testing for Film-Coated Tablets

March 31, 2025 Admin

Troubleshooting Variability in Thickness Testing for Film-Coated Tablets Troubleshooting Variability in Thickness Testing for Film-Coated Tablets Introduction: In the pharmaceutical industry, the production of film-coated tablets is a critical process that requires meticulous quality control. Thickness testing of these tablets is vital as it ensures uniformity, stability, and efficacy of the dosage form. Variability in…

Solid Dosage form, Tablets

How to Optimize Roller Compaction Parameters for Granule Uniformity

March 31, 2025 Admin

How to Optimize Roller Compaction Parameters for Granule Uniformity How to Optimize Roller Compaction Parameters for Granule Uniformity What is Roller Compaction in Granulation? Roller compaction is a dry granulation process used to produce granules by compacting powder blends between two rollers. The resulting compacted ribbons are milled to form granules of the desired size….

Tablets

Investigating Root Causes of Hardness Variability in Coated Tablets

March 31, 2025 Admin

Investigating Root Causes of Hardness Variability in Coated Tablets Investigating Root Causes of Hardness Variability in Coated Tablets Introduction: The pharmaceutical industry is committed to ensuring the quality, efficacy, and safety of its products. Among the various dosage forms, coated tablets are one of the most commonly used due to their convenience, stability, and ease…

Solid Dosage form, Tablets

Poor reproducibility in gelatin elasticity data under various storage conditions.

March 31, 2025 Admin

Poor reproducibility in gelatin elasticity data under various storage conditions. Poor reproducibility in gelatin elasticity data under various storage conditions. Introduction: Gelatin capsules, both hard and soft gelatin, are pivotal in the pharmaceutical industry as they offer a stable and effective medium for drug delivery. However, the elasticity of gelatin, a critical factor in capsule…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Compatibility Studies Between APIs and Excipients

March 31, 2025 Admin

Compatibility Studies Between APIs and Excipients Guide to Compatibility Studies Between APIs and Excipients Ensuring Stable and Effective Drug Formulations Compatibility studies between active pharmaceutical ingredients (APIs) and excipients are critical in drug formulation development. The success of a formulation depends on ensuring that the API remains stable and effective when combined with excipients. This…

Drug Discovery

Troubleshooting Dissolution Failures in Formulated Tablets

March 30, 2025 Admin

Troubleshooting Dissolution Failures in Formulated Tablets How to Troubleshoot and Fix Dissolution Failures in Tablet Formulations Overview: Dissolution failures in pharmaceutical tablet formulations can compromise drug bioavailability, regulatory compliance, and therapeutic efficacy. The failure to meet dissolution criteria may arise due to issues related to API properties, formulation composition, coating defects, or manufacturing processes. This…

Tablets

Troubleshooting Failures in Stability Testing for Film-Coated Tablets

March 30, 2025 Admin

Troubleshooting Failures in Stability Testing for Film-Coated Tablets Troubleshooting Failures in Stability Testing for Film-Coated Tablets Introduction: Stability testing is a critical component in the lifecycle of any pharmaceutical product, especially for film-coated tablets. These tests ensure that the product maintains its intended efficacy, safety, and quality throughout its shelf life. Stability testing evaluates how…

Solid Dosage form, Tablets

Addressing Non-Uniform Coating Layers in Sustained Release Tablets

March 30, 2025 Admin

Addressing Non-Uniform Coating Layers in Sustained Release Tablets Addressing Non-Uniform Coating Layers in Sustained Release Tablets Introduction: In the pharmaceutical industry, sustained release tablets play a crucial role in ensuring consistent drug delivery over an extended period. The coating of these tablets is not just a protective layer but a critical component that influences the…

Solid Dosage form, Tablets

Troubleshooting Adhesion Issues in Multi-Layer Coated Tablets

March 30, 2025 Admin

Troubleshooting Adhesion Issues in Multi-Layer Coated Tablets Troubleshooting Adhesion Issues in Multi-Layer Coated Tablets What Are Adhesion Issues in Multi-Layer Coated Tablets? Adhesion issues occur when layers of coating in multi-layer tablets fail to bond properly. This can result in peeling, cracking, or delamination, compromising the tablet’s appearance, functionality, and drug release profile. Adhesion problems…

Tablets