Author: Admin

How to Control Granule Hardness for Improved Tablet Compression

April 2, 2025 Admin

How to Control Granule Hardness for Improved Tablet Compression How to Control Granule Hardness for Improved Tablet Compression Why is Granule Hardness Important for Tablet Compression? Granule hardness refers to the strength and cohesion of granules produced during the granulation process. Proper granule hardness is essential for achieving uniform compression, optimal tablet hardness, and consistent…

Tablets

Difficulty in detecting powder buildup in filling equipment.

April 2, 2025 Admin

Difficulty in detecting powder buildup in filling equipment. Difficulty in detecting powder buildup in filling equipment. Introduction: The pharmaceutical industry heavily relies on precision and efficiency, particularly in the production of solid oral dosage forms like capsules. Filling equipment plays a crucial role in ensuring that each capsule meets stringent quality standards. However, one persistent…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Developing Enteric-Coated Tablets for Gastric Acid-Resistant Drug Delivery

April 2, 2025 Admin

Developing Enteric-Coated Tablets for Gastric Acid-Resistant Drug Delivery Step-by-Step Guide to Developing Enteric-Coated Tablets for Gastric Acid-Resistant Drug Delivery Overview: Enteric-coated tablets are designed to prevent drug release in the acidic environment of the stomach and ensure that the active pharmaceutical ingredient (API) reaches the small intestine for absorption. This coating is essential for drugs…

Tablets

High-Throughput Formulation Screening Techniques

April 2, 2025 Admin

High-Throughput Formulation Screening Techniques How to Apply High-Throughput Formulation Screening Techniques Accelerating Drug Formulation Development with Automated Testing High-throughput formulation screening techniques allow for the rapid testing of a large number of drug formulations in a short period. These techniques are particularly useful during the early stages of drug development when researchers need to test…

Drug Discovery

Poor reproducibility in vacuum sealing of capsule containers.

April 1, 2025 Admin

Poor reproducibility in vacuum sealing of capsule containers. Poor Reproducibility in Vacuum Sealing of Capsule Containers Introduction: In the pharmaceutical industry, ensuring the integrity and stability of capsule packaging is crucial. Capsules, whether hard or soft gelatin, are sensitive to environmental factors such as moisture and oxygen, which can compromise their efficacy and shelf life….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating the performance of capsule filling equipment.

April 1, 2025 Admin

Challenges in validating the performance of capsule filling equipment. Challenges in validating the performance of capsule filling equipment. Introduction: In the pharmaceutical industry, capsule filling equipment plays a crucial role in the production of solid oral dosage forms. These machines are responsible for accurately filling hard and soft gelatin capsules with the appropriate dosage of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate methods for detecting trace levels of insoluble residues.

April 1, 2025 Admin

Inadequate methods for detecting trace levels of insoluble residues. Inadequate Methods for Detecting Trace Levels of Insoluble Residues Introduction: In the pharmaceutical industry, the integrity and purity of drug products are paramount. Particularly with solid oral dosage forms, such as capsules, ensuring that no insoluble residues remain is critical for both efficacy and patient safety….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule drying processes for thermosensitive APIs.

April 1, 2025 Admin

Difficulty in validating capsule drying processes for thermosensitive APIs. Difficulty in validating capsule drying processes for thermosensitive APIs Introduction: In the realm of pharmaceutical manufacturing, ensuring the stability and efficacy of Active Pharmaceutical Ingredients (APIs) is paramount. Thermosensitive APIs, which are prone to degradation at elevated temperatures, pose unique challenges. As capsules, especially hard and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Granule Segregation During Drying and Milling

April 1, 2025 Admin

Managing Granule Segregation During Drying and Milling How to Manage Granule Segregation During Drying and Milling What is Granule Segregation? Granule segregation refers to the separation of particles or granules based on size, density, or composition during processing steps such as drying and milling. Segregation can result in inconsistent granule properties, poor flowability, uneven drug…

Tablets

Challenges in Multi-API Tablet Formulations for Sustained Release

April 1, 2025 Admin

Challenges in Multi-API Tablet Formulations for Sustained Release Exploring the Challenges and Innovations in Multi-API Tablet Formulations for Sustained Release Overview: Multi-API sustained release (SR) tablets are designed to deliver multiple active pharmaceutical ingredients (APIs) at controlled rates, improving therapeutic efficacy and patient compliance. However, developing such formulations poses significant challenges due to API incompatibility,…

Tablets

Challenges in achieving consistent gelatin solution spread during validation.

April 1, 2025 Admin

Challenges in achieving consistent gelatin solution spread during validation. Challenges in achieving consistent gelatin solution spread during validation Introduction: In the realm of pharmaceutical manufacturing, ensuring the consistency of gelatin solution spread during the validation phase of capsule production is critical. Gelatin, being a key component in both hard and soft capsules, plays a vital…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating temperature controls for gelatin solution preparation tanks.

April 1, 2025 Admin

Challenges in validating temperature controls for gelatin solution preparation tanks. Challenges in Validating Temperature Controls for Gelatin Solution Preparation Tanks Introduction: The pharmaceutical industry demands precision and reliability in every aspect of drug manufacturing, especially when it comes to solid oral dosage forms such as capsules. Gelatin, a key ingredient in both hard and soft…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms